Results 261 to 270 of about 168,707,534 (305)
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Science, 1964
Erythromycin, a specific inhibitor of protein biosynthesis, inhibited the incorporation of phenylalanine by a cell-free ribosomal system prepared from Escherichia coli .
A D, WOLFE, F E, HAHN
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Erythromycin, a specific inhibitor of protein biosynthesis, inhibited the incorporation of phenylalanine by a cell-free ribosomal system prepared from Escherichia coli .
A D, WOLFE, F E, HAHN
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Biochemical Pharmacology, 1968
Abstract Alanosine inhibits the synthesis of RNA adenine from formate- 14 C and from glycine- 14 C in Ehrlich ascites tumor cells in vivo . There is no appreciable depression of the rate of RNA guanine synthesis. The incorporation of preformed adenine- 14 C into RNA purines is unaffected.
G R, Gale, G B, Schmidt
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Abstract Alanosine inhibits the synthesis of RNA adenine from formate- 14 C and from glycine- 14 C in Ehrlich ascites tumor cells in vivo . There is no appreciable depression of the rate of RNA guanine synthesis. The incorporation of preformed adenine- 14 C into RNA purines is unaffected.
G R, Gale, G B, Schmidt
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On the mode of action of thymosin
Cellular Immunology, 1973Abstract Thymosin was administered to CBA mice which had been depleted of recirculating small lymphocytes by combining ALS and thymectomy or through lethal irradiation of thymectomised mice reconstituted with syngeneic bone marrow. The population of recirculating small lymphocytes was monitored by determining the numbers of “lymph node localising ...
Lance, E M +4 more
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The Mode of Action of Thrombin
Thrombosis and Haemostasis, 1958SummaryThe peptides liberated from fibrinogen by the action of thrombin have been isolated on modified cellulose adsorbents. These peptides have been characterized by sedimentation-diffusion measurements by quantitative amino acid analysis, and by C-terminal analysis. Both peptides were found to contain arginine as C-terminal amino acid.
K, LAKI +3 more
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Nature, 1967
A BIOCHEMICAL explanation for the antimicrobial activity of penicillin has been proposed1. In this hypothesis the structure of penicillin was related to that of intermediates known to be involved in the synthesis of cell wall material2. It was suggested that penicillin interferes with a transpeptidation reaction responsible for the cross-linking of ...
B F, Erlanger, L, Goode
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A BIOCHEMICAL explanation for the antimicrobial activity of penicillin has been proposed1. In this hypothesis the structure of penicillin was related to that of intermediates known to be involved in the synthesis of cell wall material2. It was suggested that penicillin interferes with a transpeptidation reaction responsible for the cross-linking of ...
B F, Erlanger, L, Goode
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Mode of Action of Fluoroquinolones
Drugs, 1999The mode of action of quinolones involves interactions with both DNA gyrase, the originally recognised drug target, and topoisomerase IV, a related type II topoisomerase. In a given bacterium these 2 enzymes often differ in their relative sensitivities to many quinolones, and commonly DNA gyrase is more sensitive in gram-negative bacteria and ...
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2019
The dry antibiotic development pipeline coupled with the emergence of multi-drug resistant Gram-negative 'superbugs' has driven the revival of the polymyxin lipopeptide antibiotics. Understanding the mode of action of antibiotics is an important precursor for optimizing their use and development.
Zhifeng, Li, Tony, Velkov
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The dry antibiotic development pipeline coupled with the emergence of multi-drug resistant Gram-negative 'superbugs' has driven the revival of the polymyxin lipopeptide antibiotics. Understanding the mode of action of antibiotics is an important precursor for optimizing their use and development.
Zhifeng, Li, Tony, Velkov
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Mode of action of benzimidazoles
Parasitology Today, 1990Benzimidazoles represent the only class of truly broad-spectrum anthelmintics, however, they also show activity against fungi and mammalian cells. This raises the question as to why benzimidazoles can selectively kill helminths and yet exhibit little or no mammalian toxicity.
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THE MODE OF ACTION OF CARISOPRODOL*
Annals of the New York Academy of Sciences, 1960J, DEL CASTILLO, T E, NELSON
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Pest Management Science, 2004
AbstractThe last few years have seen the introduction of an unprecedented number of new classes of acaricides with novel or under‐exploited modes of action, discovered by traditional screening. Acaricide research has uncovered several unrelated compounds that possess improved properties.
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AbstractThe last few years have seen the introduction of an unprecedented number of new classes of acaricides with novel or under‐exploited modes of action, discovered by traditional screening. Acaricide research has uncovered several unrelated compounds that possess improved properties.
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