Results 81 to 90 of about 1,500,611 (328)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Model-based Methods of Classification: Using the mclust Software in Chemometrics
Journal of Statistical Software, 2007 Due to recent advances in methods and software for model-based clustering, and to the interpretability of the results, clustering procedures based on probability models are increasingly preferred over heuristic methods. The clustering process estimates a
Chris Fraley, Adrian E. Raftery
doaj
Recommendation algorithm based on GMM clustering and FOA-GRNN model
网络与信息安全学报, 2018 Aiming at the problem of low recommendation accuracy caused by sparse data in traditional item-based recommendation algorithm,a recommendation algorithm based on GMM clustering and FOA-GRNN model is proposed.The algorithm firstly uses Gaussian mixture ...
Yipeng LI, Yeli RUAN, Jie ZHANG
doaj +3 more sources
Fuzzy model-based sparse clustering with multivariate t-mixtures
Applied Artificial Intelligence, 2023 Model-based clustering technique is an optimal choice for the distribution of data sets and to find the real structure using mixture of probability distributions.
Wajid Ali +3 more
doaj +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Comparison of Clustering Methods for Time Course Genomic Data: Applications to Aging Effects
, 2014 Time course microarray data provide insight about dynamic biological processes. While several clustering methods have been proposed for the analysis of these data structures, comparison and selection of appropriate clustering methods are seldom discussed.
Horvath, Steve +3 more
core
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Clustering Scientific Document Based on an Extended Citation Model
IEEE Access, 2019 With the number of published scientific paper increasing exponentially, scientific document clustering is becoming a challenging task. Therefore, a scientific document clustering model with high quality is needed.
Shuai Zhang, Yangbing Xu, Wenyu Zhang
doaj +1 more source
Unsupervised segmentation of mitochondria using model-based spectral clustering [PDF]
, 2013 Segmentation of mitochondria in microscopic images represents a significant challenge that is motivated by the wide morphological and structural variations that are characteristic for this category of membrane enclosed sub cellular organelles. To address
Dietlmeier, Julia +2 more
core +1 more source