Results 101 to 110 of about 9,098,363 (304)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Design of Development Environment for Embedded Control Software Based on Simulink

Kongzhi Yu Xinxi Jishu, 2014
It analyzed the problems which existed in traditional control software development methods, designed a development environment for embedded control software based on Simulink, and explained the key technologies such as automatic code generation, device ...
DAI Jisheng, CHEN Junbo, LI Cheng, LI Yi
doaj  

Developing a National Design Scoreboard [PDF]

, 2008
Recognising the growing importance of design, this paper reports on the development of an approach to measuring design at a national level. A series of measures is proposed, that are based around a simplified model of design as a system at a national ...
Beltagui, Ahmad, Demian, Peter, Evans, Steve, Livesey, Finbarr, Macbryde, Jillian, Malvido, Cecilia, Martinez, Veronica, Moultrie, James, Nixon, Bill, Pawar, Kul, Riedel, Johann   +10 more
core  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Model-Based Design and Testbed for CubeSat Attitude Determination and Control System with Magnetic Actuation

Applied Sciences
This study introduces a robust model-based framework designed for the verification and validation (V&V) of Attitude Determination and Control Systems (ADCSs) in nanosatellites, focusing on magnetic actuation while still being applicable to larger ...
Franklin Josue Ticona Coaquira, Xinsheng Wang, Karen Wendy Vidaurre Torrez, Misael Jhamel Mamani Quiroga, Miguel Angel Silva Plata, Grace Abigail Luna Verdueta, Sandro Estiven Murillo Quispe, Guillermo Javier Auza Banegas, Franz Pablo Antezana Lopez, Arturo Rojas   +9 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Model-based Design of the COAST Guidewire Robot for Large Deflection. [PDF]

IEEE Robot Autom Lett, 2023
Chitalia Y, Sarma A, Brumfiel TA, Deaton NJ, Sheft M, Desai JP, Fellow IEEE.   +6 more
europepmc   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Applying the Case-Based Axiomatic Design Assistant (CADA) to a Pharmaceutical Engineering Task: Implementation and Assessment

Computers
Modern custom machine construction and automation projects face pressure to shorten innovation cycles, reduce durations, and manage growing system complexity.
Roland Wölfle, Irina Saur-Amaral, Leonor Teixeira   +2 more
doaj   +1 more source