Results 111 to 120 of about 5,793,293 (269)

Model-Based Design of a Synthetic Oscillator Based on an Epigenetic Methylation Memory System. [PDF]

ACS Synth Biol, 2022
Klingel V, Graf D, Weirich S, Jeltsch A, Radde NE.   +4 more
europepmc   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Domino D4.1 - Initial model design

, 2018
This technical deliverable describes the model design used in Domino. Domino deploys an agent-based model that has been developed following the Gaia methodology. This deliverable contains the requirements, specification and design of the model.
Delgado, L., Cook, A.J., Gurtner, G., Pilon, N., Valput, D., Cristobal, S., Tanner, G.   +6 more
core  

UI-Design driven model-based testing

, 2009
Testing interactive systems is notoriously difficult. Not only do we need to ensure that the functionality of the developed system is correct with respect to the requirements and specifications, we also need to ensure that the user interface to the ...
Reeves, Steve, Steve Reeves, Judy Bowen, Bowen, Judy   +3 more
core   +1 more source

Socioecological model-based design and implementation principles of lower limb preservation programs as partners for limb-loss rehabilitation programs- A mini-review. [PDF]

Front Rehabil Sci, 2022
Khetarpaul V, Kirby JP, Geraghty P, Felder J, Grover P.   +4 more
europepmc   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Design Guidelines for Agent Based Model Visualization [PDF]

In the field of agent-based modeling (ABM), visualizations play an important role in identifying, communicating and understanding important behavior of the modeled phenomenon.
Uri Wilensky, Daniel Kornhauser, William Rand   +2 more
core  

Design Education as a Catalyst for Change

, 2018
Designers play a role in shaping our world, both literally and figuratively. Human lives are spent interacting with designed artefacts, systems, and processes.
Mulder, Ingrid, Ingrid Mulder, Milton, Alex, Alex Milton, Storni, Cristiano, Donál Holland, Cristiano Storni, Holland, Dónal, Maze, Ramia, Ramia Mazé   +9 more
core   +1 more source

Model-Based FPGA Implementation of a 6-DoF Dynamical Model Accelerator

IEEE Access
The mathematical model of 6-DoF dynamics is used in different applications. In general, software-based solutions are utilized to implement the 6-DoF dynamic model. This paper introduces the FPGA-based implementation of the 6-DoF dynamics accelerator. The
Sezer Memis, Ramazan Yeniceri
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source