Results 31 to 40 of about 879,678 (198)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Handling Complexity in Virtual Battery Development with a Simplified Systems Modeling Approach

World Electric Vehicle Journal
Lithium-ion battery systems are a core component for electric mobility, which has become increasingly important in the last decade. The rising number of new manufacturers and model variants also increases competitive pressure.
Achim Kampker, Heiner H. Heimes, Moritz H. Frieges, Benedikt Späth, Eva Bauer   +4 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Utilization of system models in model-based systems engineering: definition, classes and research directions based on a systematic literature review

Design Science
The use of system models within model-based systems engineering (MBSE) is essential for improved communication or system documentation. Previous publications have investigated further reuse of these system models, for example, transforming them directly ...
Fabian Wilking, Dennis Horber, Stefan Goetz, Sandro Wartzack   +3 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Environmental Assumptions in System Design: A Phenomenon-Based and Operational Perspective

IEEE Access
Invalid environment assumptions have been identified as a root cause of failures in many systems. Industrial experience shows that it is often easier to overlook environmental behaviors than system specifications, largely because environment assumptions ...
Mounifah Alenazi, Nan Niu, Latifah T. Alshammary   +2 more
doaj   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

A Categorization of Digital Twin and Model-Based System Engineering Interactions

Applied Sciences
The main goal of this study was to provide a new categorization of the different types of interactions between model-based system engineering (MBSE) and digital twins (DTs).
Alexandre Crepory Abbott de Oliveira, Renato Alves Borges   +1 more
doaj   +1 more source

Study on the overall design method of ship power system engineering based on MBSE

Zhongguo Jianchuan Yanjiu, 2023
In order to improve the overall positive design ability of ship power engineering, the digital design method of ship power systems engineering is studied. The model-based systems engineering (MBSE) method theory was integrated with the system engineering
Yuanlong YANG, Qinglin HE, Wei WU, Ling SUN   +3 more
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source