Results 51 to 60 of about 45,910,073 (298)

Model-Based Self-Managing Systems Engineering [PDF]

16th International Workshop on Database and Expert Systems Applications (DEXA'05), 2006
For many years, the vision of smart computing where systems can function and/or manage themselves independently from human intervention has provided numerous theoretical challenges to research communities ranging from intelligent systems and cybernetics to AI communities.
A. Taleb-Bendiab, David W. Bustard, Roy Sterritt, A. G. Laws, Frank Keenan   +4 more
openaire   +2 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Handling Complexity in Virtual Battery Development with a Simplified Systems Modeling Approach

World Electric Vehicle Journal
Lithium-ion battery systems are a core component for electric mobility, which has become increasingly important in the last decade. The rising number of new manufacturers and model variants also increases competitive pressure.
Achim Kampker, Heiner H. Heimes, Moritz H. Frieges, Benedikt Späth, Eva Bauer   +4 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Model-based systems engineering for life-sciences instrumentation development [PDF]

, 2018
Next‐generation genome sequencing machines and Point‐of‐Care (PoC) in vitro diagnostics devices are precursors of an emerging class of Cyber‐Physical Systems (CPS), one that harnesses biomolecular‐scale mechanisms to enable novel “wet‐technology ...
Svendsen, Winnie Edith, Madsen, Jan, Patou, François, Dimaki, Maria, Winnie E. Svendsen, Maria Dimaki, Maier, Anja, Jan Madsen, Anja Maier, Svendsen, Winnie E., François Patou   +10 more
core   +1 more source

Virtual Testing Workflows Based on the Function-Oriented System Architecture in SysML: A Case Study in Wind Turbine Systems

Wind, 2022
Wind turbines (WT) are complex multidisciplinary systems containing a large number of mechanical, control, and electrical components. Model-Based Systems Engineering (MBSE) provides an approach for cross-discipline development to address the system ...
Yizhe Zhang, Julian Roeder, Georg Jacobs, Joerg Berroth, Gregor Hoepfner   +4 more
doaj   +1 more source

Economic Analysis of Model-Based Systems Engineering [PDF]

Systems, 2019
In the face of ever-increasing complexity of systems and system development programs, several aerospace, automotive, and defense organizations have already begun or are contemplating the transition to model-based systems engineering (MBSE). The key challenges that organizations face in making this decision are determining whether it is technically ...
Madni, Azad M., Purohit, Shatad
openaire   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source