Results 71 to 80 of about 45,910,073 (298)

Constructing True Model-Based Requirements in SysML

open access: yesSystems, 2019
Some authors suggest that transitioning requirements engineering from the traditional statements in natural language with shall clauses to model-based requirements within a Model-Based Systems Engineering (MBSE) environment could improve communication ...
Alejandro Salado, Paul Wach
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Early Design Space Exploration with Model-Based System Engineering and Set-Based Design

open access: yesSystems, 2018
Adequately exploring the tradespace in the early system design phase is important to determine the best design concepts to pursue in the next life cycle stage. Tradespace exploration (TSE) often uses trade-off analysis.
Eric Specking   +3 more
doaj   +1 more source

Model-based simulation systems engineering

open access: yes, 2018
Synergien spielen eine entscheidende Rolle in der Entwicklung der Simulationsdisziplin. Der Beitrag des Fachbereichs Systems Engineering zur Simulation besteht in der Einführung von Methoden, die das Engineering von Simulationen speziell für große und komplexe Systeme verbessern.
openaire   +2 more sources

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

Meadmore Model Engineering Company.

open access: yes, 1920
Cover subtitle: Scale models of all varieties.; Electronic reproduction. Canberra, A.C.T.
Meadmore Model Engineering Co.
core  

Status Analysis of Technical-Engineering Discipline Based on the Cybernetic Model of Science and Technology

open access: yesآموزش مهندسی ایران, 2010
Based on the tow big scientific revolutions, the functions including education, research, social services and technology and academic entrepreneurship were the missions of universities especially technical-engineering discipline.
Reza Mahdi
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

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