Results 71 to 80 of about 1,285,257 (315)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Environmental Assumptions in System Design: A Phenomenon-Based and Operational Perspective
IEEE AccessInvalid environment assumptions have been identified as a root cause of failures in many systems. Industrial experience shows that it is often easier to overlook environmental behaviors than system specifications, largely because environment assumptions ...
Mounifah Alenazi +2 more
doaj +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
The Impact of Petri Nets on System-of-Systems Engineering [PDF]
, 2009 The successful engineering of a large-scale system-of-systems project towards deterministic behaviour depends on integrating autonomous components using international communications standards in accordance with dynamic requirements.
SINCLAIR, KIRSTEN,MHAIRI
core
Constructing True Model-Based Requirements in SysML
Systems, 2019 Some authors suggest that transitioning requirements engineering from the traditional statements in natural language with shall clauses to model-based requirements within a Model-Based Systems Engineering (MBSE) environment could improve communication ...
Alejandro Salado, Paul Wach
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Knowledge based system development as an engineering process [PDF]
, 1989 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Knowledge Based System (KBS) development is a difficult and challenging task, in particular in knowledge intensive domains.
Davoodi, M
core
Rapid and accurate reverse engineering of geometry based on a multi-sensor system [PDF]
, 2014 The reduction of the lead time in measurement and reverse engineering, and the increased requirements in terms of accuracy and flexibility, have resulted in a great deal of research effort aimed at developing and implementing multi-sensor systems.
Longstaff, Andrew P. +8 more
core +1 more source
Early Design Space Exploration with Model-Based System Engineering and Set-Based Design
Systems, 2018 Adequately exploring the tradespace in the early system design phase is important to determine the best design concepts to pursue in the next life cycle stage. Tradespace exploration (TSE) often uses trade-off analysis.
Eric Specking +3 more
doaj +1 more source