Controlling Concurrent Change - A Multiview Approach Toward Updatable Vehicle Automation Systems [PDF]
, 2019 The development of SAE Level 3+ vehicles [{SAE}, 2014] poses new challenges not only for the functional development, but also for design and development processes. Such systems consist of a growing number of interconnected functional, as well as hardware
+3 more
core +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Early Design Space Exploration with Model-Based System Engineering and Set-Based Design
Systems, 2018 Adequately exploring the tradespace in the early system design phase is important to determine the best design concepts to pursue in the next life cycle stage. Tradespace exploration (TSE) often uses trade-off analysis.
Eric Specking +3 more
doaj +1 more source
Model-based Engineering of Autonomous Systems using Ontologies and Metamodels [PDF]
, 2016 Our research focuses on engineering processes for autonomous intelligent systems construction with a life-cycle holistic view, by means of a model-based framework. The conceptual core of the framework is ontologically-driven.
Bermejo Alonso, Julita +2 more
core +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
A MDE-based optimisation process for Real-Time systems [PDF]
, 2010 The design and implementation of Real-Time Embedded Systems is now heavily relying on Model-Driven Engineering (MDE) as a central place to define and then analyze or implement a system.
Gilles, Olivier, Hugues, Jérôme
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In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Reliability Analysis of Complex NASA Systems with Model-Based Engineering [PDF]
The emergence of model-based engineering, with Model- Based Systems Engineering (MBSE) leading the way, is transforming design and analysis methodologies.
Alimardani, Mahdi +2 more
core +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Modeling and Simulation of Satellite Communication System Base on MBSE
天地一体化信息网络, 2021 A method based on model-based systems engineering (MBSE) for the demonstration, top-level design and engineering construction of the satellite communication system was introduced, which was aim at the problem of design, description, verification and ...
Wenping LI +4 more
doaj +2 more sources