Results 81 to 90 of about 1,285,257 (315)

Model-based simulation systems engineering

open access: yes, 2018
Synergien spielen eine entscheidende Rolle in der Entwicklung der Simulationsdisziplin. Der Beitrag des Fachbereichs Systems Engineering zur Simulation besteht in der Einführung von Methoden, die das Engineering von Simulationen speziell für große und komplexe Systeme verbessern.
openaire   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Set-Based Concurrent Engineering process within the LeanPPD environment [PDF]

open access: yes, 2011
This paper presents a newly defined set-based concurrent engineering process, which the authors believe addresses some of the key challenges faced by engineering enterprises in the 21st century. The main principles of Set-Based Concurrent Engineering (
Shehab, Essam   +11 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

V-Model Role Engineering [PDF]

open access: yes
The paper focuses on role engineering which is an important topic in the development of access control system, particularly when considering Role Based Access Control – RBAC models.
Radu CONSTANTINESCU
core  

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The use of system dynamics group model building for analysing event causality within the nuclear industry [PDF]

open access: yes, 2010
Currently the most frequently used tools for investigating and learning from industrial accidents are based on linear, reductionist models of event causality.
Carhart, NJ, Yearworth, M
core  

Model-based product line engineering for embedded real-time systems [PDF]

open access: yes, 2020
Product Line Engineering (PLE) has attracted attention in the last two decades due to its promising capabilities to reduce system life-cycle costs and time to market through the reuse of requirements and components.
Mole Li (1258866)
core   +1 more source

Status Analysis of Technical-Engineering Discipline Based on the Cybernetic Model of Science and Technology

open access: yesآموزش مهندسی ایران, 2010
Based on the tow big scientific revolutions, the functions including education, research, social services and technology and academic entrepreneurship were the missions of universities especially technical-engineering discipline.
Reza Mahdi
doaj   +1 more source

Modeling and Simulation of Satellite Communication System Base on MBSE

open access: yes天地一体化信息网络, 2021
A method based on model-based systems engineering (MBSE) for the demonstration, top-level design and engineering construction of the satellite communication system was introduced, which was aim at the problem of design, description, verification and ...
Wenping LI   +4 more
doaj   +2 more sources

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