Results 61 to 70 of about 45,910,073 (298)

Utilization of system models in model-based systems engineering: definition, classes and research directions based on a systematic literature review

Design Science
The use of system models within model-based systems engineering (MBSE) is essential for improved communication or system documentation. Previous publications have investigated further reuse of these system models, for example, transforming them directly ...
Fabian Wilking, Dennis Horber, Stefan Goetz, Sandro Wartzack   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A Complexity Analysis Approach for Model-based System Engineering

, 2020
With the increasing complexity of the highly engineered products, Model-based Systems Engineering (MBSE) is proposed to support the complexity management of the product development.
Jinwei Chen, Xiaochen Zheng, Dimitrios Kyritsis, Jinzhi Lu, Zhang, Huisheng, Lu, Jinzhi, Hu, Zhenchao, Zheng, Xiaochen, Chen, Jinwei, Zhenchao Hu, Kyritsis, Dimitrios, Huisheng Zhang   +11 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Semantic-based policy engineering for autonomic systems [PDF]

, 2004
This paper presents some important directions in the use of ontology-based semantics in achieving the vision of Autonomic Communications. We examine the requirements of Autonomic Communication with a focus on the demanding needs of ubiquitous computing ...
Carey, Kevin, Lewis, D., Carey, K., Simon Courtenage, Thanassis Tiropanis, Courtenage, Simon, Kevin Carey, Feeney, Kevin, Tiropanis, Thanassis, Tiropanis, T., Lewis, David, Courtenage, S., Kevin Feeney, Feeney, K., David Lewis   +14 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Environmental Assumptions in System Design: A Phenomenon-Based and Operational Perspective

IEEE Access
Invalid environment assumptions have been identified as a root cause of failures in many systems. Industrial experience shows that it is often easier to overlook environmental behaviors than system specifications, largely because environment assumptions ...
Mounifah Alenazi, Nan Niu, Latifah T. Alshammary   +2 more
doaj   +1 more source

Improving the Model-Based Systems Engineering Process [PDF]

, 2022
AbstractModern embedded software systems are becoming more and more complex. Engineering embedded systems raise specific challenges that are rarely present in other software engineering disciplines due to the systems’ steady interactions with their environment.
openaire   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source