Results 61 to 70 of about 1,285,257 (315)
Economic Analysis of Model-Based Systems Engineering [PDF]
Systems, 2019 In the face of ever-increasing complexity of systems and system development programs, several aerospace, automotive, and defense organizations have already begun or are contemplating the transition to model-based systems engineering (MBSE). The key challenges that organizations face in making this decision are determining whether it is technically ...
Azad M. Madni, Shatad Purohit
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FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
A European emotional investigation in the field of shoes design [PDF]
, 2009 http://inderscience.metapress.com/content/lujq27m40g324256/In this paper we report on the results of a Kansei Engineering System study. A methodology for the application of Kansei Engineering at a European level has been developed and validated in the ...
AOUSSAT, Améziane +6 more
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Design ScienceThe use of system models within model-based systems engineering (MBSE) is essential for improved communication or system documentation. Previous publications have investigated further reuse of these system models, for example, transforming them directly ...
Fabian Wilking +3 more
doaj +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
A Categorization of Digital Twin and Model-Based System Engineering Interactions
Applied SciencesThe main goal of this study was to provide a new categorization of the different types of interactions between model-based system engineering (MBSE) and digital twins (DTs).
Alexandre Crepory Abbott de Oliveira +1 more
doaj +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
An engineering design knowledge reuse methodology using process modelling [PDF]
, 2007 This paper describes an approach for reusing engineering design knowledge. Many previous design knowledge reuse systems focus exclusively on geometrical data, which is often not applicable in early design stages.
Young, Bob +9 more
core +1 more source
Improving the Model-Based Systems Engineering Process [PDF]
, 2022 AbstractModern embedded software systems are becoming more and more complex. Engineering embedded systems raise specific challenges that are rarely present in other software engineering disciplines due to the systems’ steady interactions with their environment.
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