Results 101 to 110 of about 45,910,073 (298)

Organizational Simulation for Model Based Systems Engineering

Procedia Computer Science, 2013
AbstractOrganizations creating complex systems often have hierarchical team networks; this structure affects system performance because some teams have greater influence over dimensions of parts produced by other teams. Dimensional interdependencies among components produce ripple-effects; examples include load paths and thermal flows.
Daniel A. O'Neil, Mikel D. Petty
openaire   +2 more sources

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Development of a Body Weight Support System Employing Model-Based System Engineering Methodology

Technologies
Partial body weight support systems have proven to be a vital tool in performing physical therapy for patients with lower limb disabilities to improve gait.
Alberto E. Loaiza, Jose I. Garcia, Jose T. Buitrago   +2 more
doaj   +1 more source

Model Based Systems Engineering for Smart Grids as Systems of Systems

Procedia Computer Science, 2011
AbstractThis paper presents a System of Systems (SOS) approach to understand, analyze, and design modern energy Smart Grids using Model-Based Systems Engineering (MBSE) methodologies. The concept and definition of a Smart Grid as SOS is presented and Smart Grids are analyzed in the form of detailed architectural artifacts with System Modeling Language (
Amit J. Lopes, R. Lezama, Ricardo Pineda
openaire   +2 more sources

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Model-based decoupling control method for dual-drive gantry stages : A case study with experimental validations [PDF]

, 2013
La version éditeur de cet article est disponible à l'adresse suivante : http://dx.doi.org/10.1016/j.conengprac.2012.10.010Industrial motion control of dual–drive gantry stages is usually performed by position controllers acting independently on each ...
COLEMAN, Ralph, GOMAND, Julien, KESTELYN, Xavier, BARRE, Pierre-Jean, GARCÍA-HERREROS, Iván   +4 more
core   +1 more source

Enhancing Model-Based Systems Engineering via Graph-Theoretic Partitioning and System Model Metrics

IEEE Open Journal of Systems Engineering
Verification, validation, and testing of complex cyber-physical systems, such as autonomous vehicles, have traditionally relied on document-intensive processes and physical prototypes. However, accelerated development timelines increasingly challenge the
Lukas Macha, Julian Padget, Peter Ebner, Chris Brace   +3 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Identification and predictive control of a multistage evaporator [PDF]

, 2010
A recurrent neural network-based nonlinear model predictive control (NMPC) scheme in parallel with PI control loops is developed for a simulation model of an industrial-scale five-stage evaporator.
Cao, Y., Tadé, M.O., J.C. Atuonwu, Rangaiah, G., Atuonwu, J.C., Atuonwu, James C., Cao, Yi, Rangaiah, G.P., Y. Cao, Atuonwu, J., Tade, Moses, Tadé, M. O., M.O. Tadé, G.P. Rangaiah, Rangaiah, G. P.   +14 more
core   +1 more source