Results 121 to 130 of about 1,285,257 (315)

Model and Quality Driven Embedded Systems Engineering [PDF]

, 2009
The world of embedded systems is broad and diverse, addressing a wide variety of application domains. Although technologically, the situation for embedded systems is still quite fragmented, platform-based engineering, reference designs and maturing ...
Vicedo, Josetxo, Tiensyrjä, Kari, Noguero, Adrian, Campos, Sergio, Ovaska, Eila, Pataricza, András, Balogh, András   +6 more
core  

Enhancing Model-Based Systems Engineering via Graph-Theoretic Partitioning and System Model Metrics

IEEE Open Journal of Systems Engineering
Verification, validation, and testing of complex cyber-physical systems, such as autonomous vehicles, have traditionally relied on document-intensive processes and physical prototypes. However, accelerated development timelines increasingly challenge the
Lukas Macha, Julian Padget, Peter Ebner, Chris Brace   +3 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Design Model Data Exchange Between Concurrent Engineering Facilities by Means of Model Transformation [PDF]

, 2011
The German Aerospace Center (DLR) is developing the software Virtual Satellite for use in their Concurrent Engineering Facility. Throughout the design process of a spacecraft the software supports engineers to store and manage the data and results of ...
Schaus, Volker, Gerndt, Andreas, Fischer, Philipp M.   +2 more
core  

Set-based design of mechanical systems with design robustness integrated [PDF]

, 2014
This paper presents a method for parameter design of mechanical products based on a set-based approach. Set-based concurrent engineering emphasises on designing in a multi-stakeholder environment with concurrent involvement of the stakeholders in the ...
DANTAN, Jean-Yves, Bigot, Régis, QURESHI, Ahmed Jawad, BRUYERE, Jérôme   +3 more
core   +2 more sources

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

The Concept Design of Rice Quality Detection System Using Model-Based System Engineering Approach

Journal of Applied Agricultural Science and Technology
Quality of rice is determined by several factors such as water content, broken grains, and whiteness. The approach often used for the measurement is manual, time-consuming, and prone to error.
Purwa Tri Cahyana, Titi Candra Sunarti, Erliza Noor, Hartrisari Hardjomidjojo, Noer Laily   +4 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Application of Harmony SE in civil aircraft design

Xibei Gongye Daxue Xuebao
With the refinement of civil aircraft technology and the enhancement of product complexity, civil aircraft design has changed from traditional text-based system engineering to model-based system engineering, the expression of the system has also ...
LIU Wanyi, FENG Yunwen, HOU Jieran, CHEN Junyu, GUO Yingnan   +4 more
doaj   +1 more source