Results 131 to 140 of about 1,285,257 (315)

Reasonable Experiments in Model-Based Systems Engineering

CoRR
With the current trend in Model-Based Systems Engineering towards Digital Engineering and early Validation & Verification, experiments are increasingly used to estimate system parameters and explore design decisions. Managing such experimental configuration metadata and results is of utmost importance in accelerating overall design effort.
Cederbladh, Johan, Cleophas, Loek, Kamburjan, Eduard, Lima, Lucas, Mittal, Rakshit, Vangheluwe, Hans   +5 more
openaire   +2 more sources

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Model inversion of electrical engineering systems from bicausal bond graphs [PDF]

, 2005
In this paper, the application of bicausal bond graphs for model inversion of typical electrical engineering systems is emphasised. Inverse models are particularly useful for the synthesis step of the system design process.
Sareni, Bruno, Gandanegara, Grace, Roboam, Xavier   +2 more
core  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Application of model based systems engineering methods to development of combat system architectures [PDF]

, 2009
Navy acquisition activities frequently produce combat system architectures based on existing systems rather than stakeholder requirements. This approach limits software component reuse which, in turn, limits potential application to other platforms ...
Hoang, Tuyen, Banner-Bacin, Linda, Kinberg, Michael, O'Neil, John, Chacon, David, Kong, James, Childs, James, Pham, Tan, Vajdos, Caleb, Sarabia, Eric, Sysavath, Heng, Ortiz, Leonard, Wheeler, Paul, Vasquez, Armando, Manz, Jeremy, Rayshouny, Jamal, Chandler, James, Valdez, Armando, Wellesley, Alan, Wentland, Mindy, Mendiola, Jonathan, Carpenter, Tim, Howard, Robert, Sung, Kihoon, Kang, Seung, Matela, Ruth, Isaian, James   +26 more
core  

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Model based code generation for distributed embedded systems [PDF]

, 2010
Embedded systems are becoming increasingly complex and more distributed. Cost and quality requirements necessitate reuse of the functional software components for multiple deployment architectures.
Gopalswamy, Swaminathan, Hugues, Jérôme, Radhakrishnan, Karthikeyan, Raghav, Gopal, Delange, Julien   +4 more
core  

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source