Results 111 to 120 of about 1,285,257 (315)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
The design model of solar powered automatic bell system integrated with smoke detection for educational institution application [PDF]
, 2018 The work presents a design model of renewable energy based automatic bell system integrated with smoke detection, which uses solar energy as main power source.
Shing Fhan, Khor; School of Electrical System Engineering, Universiti Malaysia Perlis, Pauh Putra Campus, 02600 Arau,Perlis +3 more
core
A Systems Thinking Approach to Designing Clinical Models and Healthcare Services
Systems, 2019 Chronic diseases are on the rise, increasing in number and treatment regimen complexity. Consequently, the needs of patients with chronic diseases are increasing and becoming more complex and multi-faceted.
Inas S. Khayal
doaj +1 more source
Organizational Simulation for Model Based Systems Engineering
Procedia Computer Science, 2013 AbstractOrganizations creating complex systems often have hierarchical team networks; this structure affects system performance because some teams have greater influence over dimensions of parts produced by other teams. Dimensional interdependencies among components produce ripple-effects; examples include load paths and thermal flows.
Daniel A. O'Neil, Mikel D. Petty
openaire +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Model-based engineering in real-time embedded systems: specifying timing constraints [PDF]
, 2014 This paper presents the results from a research project on development of Real-Time Embedded Systems (RTESs) using a Model-Based Engineering (MBE) approach.
Temelkovski, D., Beus-Dukic, L.
core
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
Structural Damage Evaluation: Theory and Applications to Earthquake Engineering [PDF]
, 2004 The further development of performance-based earthquake engineering (PBEE) is on the current agenda of the earthquake engineering community. A part of assessing the seismic performance of civil engineering structures involves estimation of seismic damage.
Shaikhutdinov, R. V. +1 more
core +1 more source
Model Based Systems Engineering for Smart Grids as Systems of Systems
Procedia Computer Science, 2011 AbstractThis paper presents a System of Systems (SOS) approach to understand, analyze, and design modern energy Smart Grids using Model-Based Systems Engineering (MBSE) methodologies. The concept and definition of a Smart Grid as SOS is presented and Smart Grids are analyzed in the form of detailed architectural artifacts with System Modeling Language (
Amit J. Lopes, R. Lezama, Ricardo Pineda
openaire +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source