Results 111 to 120 of about 45,910,073 (298)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Coordinating Agile Systems through the Model-based Execution of Temporal Plans [PDF]

, 2006
SM thesisAgile autonomous systems are emerging, such as unmanned aerial vehicles (UAVs), that must robustly perform tightly coordinated time-critical missions; for example, military surveillance or search-and-rescue scenarios.
Leaute, Thomas
core  

Bond graph analysis in robust engineering design [PDF]

, 2000
Within engineering design, optimization often involves building models of working systems to improve design objectives such as performance, reliability and cost.
GABBRIELLI R., de Mast, J., Does, R.J.M.M., BRAGLIA, MARCELLO, van den Heuvel, E.R., BRAGLIA M., Heuvel, van den, E.R., Bates, RA, YANG, Zhenlin, BEVILACQUA M., Atherton, MA, GABBRIELLI, ROBERTO, Bates, R. A., Yang, Z., Schippers, W.A.J., Atherton, M. A., Mast, de, J., Does, R.J.M.M.; id_orcid, BEVILACQUA, MAURIZIO, Wu, Shuo-jye; Tsai, Tzong-ru, Xie, M., Gaudoin, O., Wu, Shuo-jye   +22 more
core   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

The Concept Design of Rice Quality Detection System Using Model-Based System Engineering Approach

Journal of Applied Agricultural Science and Technology
Quality of rice is determined by several factors such as water content, broken grains, and whiteness. The approach often used for the measurement is manual, time-consuming, and prone to error.
Purwa Tri Cahyana, Titi Candra Sunarti, Erliza Noor, Hartrisari Hardjomidjojo, Noer Laily   +4 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Application of Harmony SE in civil aircraft design

Xibei Gongye Daxue Xuebao
With the refinement of civil aircraft technology and the enhancement of product complexity, civil aircraft design has changed from traditional text-based system engineering to model-based system engineering, the expression of the system has also ...
LIU Wanyi, FENG Yunwen, HOU Jieran, CHEN Junyu, GUO Yingnan   +4 more
doaj   +1 more source

Reasonable Experiments in Model-Based Systems Engineering

CoRR
With the current trend in Model-Based Systems Engineering towards Digital Engineering and early Validation & Verification, experiments are increasingly used to estimate system parameters and explore design decisions. Managing such experimental configuration metadata and results is of utmost importance in accelerating overall design effort.
Cederbladh, Johan, Cleophas, Loek, Kamburjan, Eduard, Lima, Lucas, Mittal, Rakshit, Vangheluwe, Hans   +5 more
openaire   +2 more sources

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source