Results 91 to 100 of about 39,594,929 (287)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Seamless Function-Oriented Mechanical System Architectures and Models

Eng
One major challenge of today’s product development is to master the constantly increasing product complexity driven by the interactions between different disciplines, like mechanical, electrical and software engineering.
Christian Wyrwich, Kathrin Boelsen, Georg Jacobs, Thilo Zerwas, Gregor Höpfner, Christian Konrad, Joerg Berroth   +6 more
doaj   +1 more source

Organizational Simulation for Model Based Systems Engineering

Procedia Computer Science, 2013
AbstractOrganizations creating complex systems often have hierarchical team networks; this structure affects system performance because some teams have greater influence over dimensions of parts produced by other teams. Dimensional interdependencies among components produce ripple-effects; examples include load paths and thermal flows.
Daniel A. O'Neil, Mikel D. Petty
openaire   +2 more sources

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Enhancing model-based systems engineering with the Lifecycle Modeling Language [PDF]

, 2016
As systems become more complex, the systems engineering community must find new and more efficient ways of dealing with complexity throughout the system's lifecycle.
Vaneman, Warren K.
core   +2 more sources

Engineering Systems with Standards and Digital Models: Specifying Stakeholder Needs and Capabilities—MGOS

Systems
This paper proposes a formal method and associated techniques for completing the ISO/IEC/IEEE Standard 15288 technical process 6.4.2—Stakeholder Needs and Requirements definition within the 15288-SysML Grid framework.
Kevin MacG. Adams, Irfan Ibrahim, Steven L. Krahn   +2 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

A MODEL-BASED SYSTEMS ENGINEERING STUDY OF AIRSHIPS FOR ANTI-SUBMARINE WARFARE

To support improved capability in Anti-Submarine Warfare (ASW) defense of the U.S. west coast, this research project investigates the technical and cost feasibility of developing an ASW airship.
Cromwell, Brittney L., Handrigan, John J., IV, Blanchard, Monica L., Santos, Delaney R.   +3 more
core   +2 more sources

Model Based Systems Engineering for Smart Grids as Systems of Systems

Procedia Computer Science, 2011
AbstractThis paper presents a System of Systems (SOS) approach to understand, analyze, and design modern energy Smart Grids using Model-Based Systems Engineering (MBSE) methodologies. The concept and definition of a Smart Grid as SOS is presented and Smart Grids are analyzed in the form of detailed architectural artifacts with System Modeling Language (
Amit J. Lopes, R. Lezama, Ricardo Pineda
openaire   +2 more sources