Results 81 to 90 of about 6,641,478 (335)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

open access: yesFEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi   +5 more
wiley   +1 more source

Ontology and Model Based Systems Engineering

open access: yesProcedia Computer Science, 2011
The subject of this paper is an information technology framework based on the use of an ontology that can be used for explicit and consistent specification, design, engineering, production and maintenance of complex facilities, e.g. ships and infrastructure.
openaire   +1 more source

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Combining Model-Based Systems Engineering and Knowledge-Centric Systems Engineering to Design Reliable Systems in Practice

open access: yesApplied Sciences
The use and importance of complex software-intensive systems are growing. As they are used in a wider range of situations in which dependability must be ensured, the reliability of the systems and of their components needs to be addressed throughout ...
Juan Manuel Morote   +4 more
doaj   +1 more source

A synthesis of logic and biology in the design of dependable systems [PDF]

open access: yes, 2015
The technologies of model-based design and dependability analysis in the design of dependable systems, including software intensive systems, have advanced in recent years.
Papadopoulos, Yiannis
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Microservices and Machine Learning Algorithms for Adaptive Green Buildings [PDF]

open access: yes, 2019
In recent years, the use of services for Open Systems development has consolidated and strengthened. Advances in the Service Science and Engineering (SSE) community, promoted by the reinforcement of Web Services and Semantic Web technologies and the ...
Alonso Montesinos, Joaquín Blas   +6 more
core   +1 more source

Automated post-fault diagnosis of power system disturbances [PDF]

open access: yes, 2006
In order to automate the analysis of SCADA and digital fault recorder (DFR) data for a transmission network operator in the UK, the authors have developed an industrial strength multi-agent system entitled protection engineering diagnostic agents (PEDA).
Davidson, E.M., McArthur, S.D.J.
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

A methodological proposal and tool support for the HL7 standards compliance in the development of health information systems [PDF]

open access: yes, 2017
Health information systems are increasingly complex, and their development is presented as a challenge for software development companies offering quality, maintainable and interoperable products.
Domínguez-Mayo, F.J   +7 more
core  

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