Results 81 to 90 of about 39,594,929 (287)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

EGRESS: A Methodology for Eliciting Goals for Requirements Engineering of Secure Systems

IEEE Open Journal of Systems Engineering
Currently, the systems engineering body of knowledge does not appropriately address secure system design considerations prior to a preliminary architecture being available for the system under design.
Martin Span, Gabe Salinger, Jeremy Daily
doaj   +1 more source

Implementing model-based systems engineering based on shared services

, 2022
S.104-111Two mega trends in product engineering require a re-thinking of established ways of working: The technical evolution to intelligent technical systems and the re-design of value creation networks, now integrating partners from all over the world.
Bansmann, Michael, Tschirner, Christian, Dumitrescu, Roman   +2 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Model-Based Systems Engineering Maturity Models—A Systematic Mapping Study

IEEE Open Journal of Systems Engineering
Model-based systems engineering (MBSE), as a logical progression from document-based systems engineering (SE), presents challenges for organizations in terms of both implementation and application.
Henriette Hofermann, Pascal Lunnemann, Kai Lindow   +2 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Model-Based Systems Engineering Applied to Trade-Off Analysis of Wireless Power Transfer Technologies for Implanted Biomedical Microdevices. [PDF]

Sensors (Basel), 2021
Martínez Rojas JA, Fernández JL, Sánchez Montero R, López Espí PL, Diez-Jimenez E.   +4 more
europepmc   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

APPLYING MODEL-BASED SYSTEMS ENGINEERING TO BASELINE HUGHES SALVO MODEL FOR FUTURE DEVELOPMENT

This capstone project explores how model-based systems engineering (MBSE) principles can be applied to facilitate modifications to the Hughes Salvo model and how the development of a baseline set of systems engineering artifacts can aid in future ...
Doerr, Christopher M., Johnson, Feona Mae L., Ward, Josiah H., Crooks, Keithley, Johnson, Irah   +4 more
core   +1 more source

Using a Metadata Approach to Extend the Functional Resonance Analysis Method to Model Quantitatively, Emergent Behaviours in Complex Systems

Systems
In an increasingly complex world there is a real, urgent need for methodologies to enable engineers to model complex sociotechnical systems, as these now seem to describe the majority of systems in use today.
Rees Hill, David Slater
doaj   +1 more source