Results 61 to 70 of about 680,200 (262)

Open-Source Data Formalization through Model-Based Systems Engineering for Concurrent Preliminary Design of CubeSats

Aerospace
Market trends in the space sector suggest a notable increase in satellite operations and market value for the coming decade. In parallel, there has been a shift in the industrial and academic sectors from traditional Document-Based System Engineering to ...
Giacomo Luccisano, Sophia Salas Cordero, Thibault Gateau, Nicole Viola   +3 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Product Cost Calculation in Model-Based Systems Engineering

Systems
In product development, costs play a major role in making design decisions. As such, it is desirable to have this information as early as possible in the product development process (PDP).
Georg Hartmann, Thilo Zerwas, Lisa Domröse, Kathrin Boelsen, Christian Hilger, Simon Schnürer   +5 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

EGRESS: A Methodology for Eliciting Goals for Requirements Engineering of Secure Systems

IEEE Open Journal of Systems Engineering
Currently, the systems engineering body of knowledge does not appropriately address secure system design considerations prior to a preliminary architecture being available for the system under design.
Martin Span, Gabe Salinger, Jeremy Daily
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Model-Based Systems Engineering Maturity Models—A Systematic Mapping Study

IEEE Open Journal of Systems Engineering
Model-based systems engineering (MBSE), as a logical progression from document-based systems engineering (SE), presents challenges for organizations in terms of both implementation and application.
Henriette Hofermann, Pascal Lunnemann, Kai Lindow   +2 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Using a Metadata Approach to Extend the Functional Resonance Analysis Method to Model Quantitatively, Emergent Behaviours in Complex Systems

Systems
In an increasingly complex world there is a real, urgent need for methodologies to enable engineers to model complex sociotechnical systems, as these now seem to describe the majority of systems in use today.
Rees Hill, David Slater
doaj   +1 more source

Model-Based Systems Engineering Applied to Trade-Off Analysis of Wireless Power Transfer Technologies for Implanted Biomedical Microdevices. [PDF]

Sensors (Basel), 2021
Martínez Rojas JA, Fernández JL, Sánchez Montero R, López Espí PL, Diez-Jimenez E.   +4 more
europepmc   +1 more source