Results 61 to 70 of about 39,594,929 (287)
Applying Model-Based Systems Engineering to Tailings Storage Facility Structures
Materials Proceedings, 2023 Model-based systems engineering (MBSE) is a methodology that focuses on creating and exploiting the digital system and engineering domain models as the primary means of exchange of information, feedback, and requirements, as opposed to document-centric ...
Bartłomiej Bursa +2 more
doaj +1 more source
Coordinating Agile Systems through the Model-based Execution of Temporal Plans [PDF]
, 2006 SM thesisAgile autonomous systems are emerging, such as unmanned aerial vehicles (UAVs), that must robustly perform tightly coordinated time-critical missions; for example, military surveillance or search-and-rescue scenarios.
Leaute, Thomas
core
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Applied SciencesThe use and importance of complex software-intensive systems are growing. As they are used in a wider range of situations in which dependability must be ensured, the reliability of the systems and of their components needs to be addressed throughout ...
Juan Manuel Morote +4 more
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
SystemsThe development of patient-specific medical systems poses challenges for requirements engineering and their traceable integration into system models, as regulatory frameworks require transparent and traceable links between stakeholder needs and product ...
Franziska Wieja +4 more
doaj +1 more source
An engineering design knowledge reuse methodology using process modelling [PDF]
, 2007 This paper describes an approach for reusing engineering design knowledge. Many previous design knowledge reuse systems focus exclusively on geometrical data, which is often not applicable in early design stages.
Young, Bob +9 more
core +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Improving the Model-Based Systems Engineering Process [PDF]
, 2022 AbstractModern embedded software systems are becoming more and more complex. Engineering embedded systems raise specific challenges that are rarely present in other software engineering disciplines due to the systems’ steady interactions with their environment.
openaire +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source