Results 41 to 50 of about 39,594,929 (287)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Model-based systems engineering for life-sciences instrumentation development [PDF]

, 2019
Next‐generation genome sequencing machines and Point‐of‐Care (PoC) in vitro diagnostics devices are precursors of an emerging class of Cyber‐Physical Systems (CPS), one that harnesses biomolecular‐scale mechanisms to enable novel "wet‐technology ...
Madsen, Jan, Patou, François, Dimaki, Maria, Maier, Anja, Svendsen, Winnie E.   +4 more
core   +1 more source

Towards an Automatic Test Generation Method for Systems of Systems Based on Fault Injection and Model-Based Systems Engineering

Applied Sciences, 2022
The emergence and development of systems of systems (SoSs) have expanded the complexity and adaptability of systems engineering. Due to the heterogeneity of its constituent systems, designing and analyzing an SoS faces enormous challenges. Therefore, the
Yingchun Tian, Delin Jing
doaj   +1 more source

Model-Based Self-Managing Systems Engineering [PDF]

16th International Workshop on Database and Expert Systems Applications (DEXA'05), 2006
For many years, the vision of smart computing where systems can function and/or manage themselves independently from human intervention has provided numerous theoretical challenges to research communities ranging from intelligent systems and cybernetics to AI communities.
A. Taleb-Bendiab, David W. Bustard, Roy Sterritt, A. G. Laws, Frank Keenan   +4 more
openaire   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Application of model based systems engineering methods to development of combat system architectures [PDF]

, 2009
Navy acquisition activities frequently produce combat system architectures based on existing systems rather than stakeholder requirements. This approach limits software component reuse which, in turn, limits potential application to other platforms ...
Hoang, Tuyen, Banner-Bacin, Linda, Kinberg, Michael, O'Neil, John, Chacon, David, Kong, James, Childs, James, Vajdos, Caleb, Pham, Tan, Sarabia, Eric, Sysavath, Heng, Ortiz, Leonard, Wheeler, Paul, Vasquez, Armando, Manz, Jeremy, Rayshouny, Jamal, Chandler, James, Valdez, Armando, Wellesley, Alan, Wentland, Mindy, Mendiola, Jonathan, Carpenter, Tim, Howard, Robert, Sung, Kihoon, Kang, Seung, Matela, Ruth, Isaian, James   +26 more
core   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Development of a systems engineering competency model tool for the Aviation and Missile Research, Development, and Engineering Center (AMRDEC) [PDF]

, 2017
Includes supplementary materialThe Naval Postgraduate School has developed a competency model for the systems engineering profession and is implementing a tool to support high stakes human resource functions for the U.S. Army.
Chess, Mark, Rusak, Mark, Payne, Brandon, Green, Joseph, Wright, Timothy, Christiansen, Adam, Cobb, Daniel, Jerome, David   +7 more
core   +2 more sources

A Hybrid Knowledge Extraction Method to Support Early Concurrent Engineering in the Aerospace Industry

Aerospace
In the early stages of concurrent engineering, the ability to assess design change impact is fundamentally limited by the availability of expert knowledge.
Eliott Duverger, Rebeca Arista, Alexis Aubry, Eric Levrat   +3 more
doaj   +1 more source

Toward Conceptual Analysis of Cyber-Physical Systems Projects Focusing on the Composition of Legacy Systems

IEEE Access, 2023
The increase in connectivity and the continued need to evolve existing systems impose on system engineers the reality of dealing with System of Systems (SoS) concept in practice.
Andre A. S. Ivo, Sheila Granato Ribeiro, Fatima Mattiello-Francisco, Andrea Bondavalli   +3 more
doaj   +1 more source