Results 41 to 50 of about 680,200 (262)
Model Signatures for the Integration of Simulation Models into System Models
Systems, 2022 Model-based systems engineering (MBSE) is an auspicious approach to the virtual development of cyber-physical systems. The behavior of the system’s elements is thus represented by specialized simulation models that are integrated into the descriptive ...
Thilo Zerwas +9 more
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Characterizing Efficacy of Alternative Media for Requirements Expression
SystemsRequirements are most commonly expressed in natural language, but alternative media can be employed. Previous research has established the viability of model diagrams and engineering drawings for requirements expression.
Jason Kolligs, Lawrence Dale Thomas
doaj +1 more source
Quantitative Set-Based Design to Inform Design Teams
Applied Sciences, 2021 System designers, analysts, and engineers use various techniques to develop complex systems. A traditional design approach, point-based design (PBD), uses system decomposition and modeling, simulation, optimization, and analysis to find and compare ...
Eric Specking +3 more
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Applied SciencesThe use and importance of complex software-intensive systems are growing. As they are used in a wider range of situations in which dependability must be ensured, the reliability of the systems and of their components needs to be addressed throughout ...
Juan Manuel Morote +4 more
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
SystemsThe development of patient-specific medical systems poses challenges for requirements engineering and their traceable integration into system models, as regulatory frameworks require transparent and traceable links between stakeholder needs and product ...
Franziska Wieja +4 more
doaj +1 more source