Results 51 to 60 of about 39,594,929 (287)

Systems Engineering Thesis Research Guide [PDF]

, 2013
Version 1.0This guide has been prepared for Systems Engineering (SE) students to assist them in completing the Master’s thesis. The guide focuses on the preparation, the proposal and the research element of the project, describes the roles and ...
Systems Engineering Department, Wayne E. Meyer Institute of Systems Engineering   +1 more
core  

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Bibliometric analysis of model-based systems engineering in advanced manufacturing [PDF]

Journal of Intelligent Manufacturing and Special Equipment
Purpose – Model-based systems engineering (MBSE) is an important approach for the transforming process from “document-centered” to “model centered” systems engineering mode in equipment development, which can effectively shorten the equipment development
Jinzhi Lu, Yihui Gong, Guoxin Wang, Yan Yan   +3 more
doaj   +1 more source

Automated Piping in an Airbus A320 Landing Gear Bay Using Graph-Based Design Languages

Aerospace, 2022
System design in an aircraft is still a costly, manual and iterative approach. One major cost driver of changes in system installation are design efforts for creating new pipes in an earlier stage and the costs accumulated during the in service life.
Moritz Neumaier, Stefan Kranemann, Bernd Kazmeier, Stephan Rudolph   +3 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Model Signatures for the Integration of Simulation Models into System Models

Systems, 2022
Model-based systems engineering (MBSE) is an auspicious approach to the virtual development of cyber-physical systems. The behavior of the system’s elements is thus represented by specialized simulation models that are integrated into the descriptive ...
Thilo Zerwas, Georg Jacobs, Julia Kowalski, Stephan Husung, Detlef Gerhard, Bernhard Rumpe, Klaus Zeman, Seyedmohammad Vafaei, Florian König, Gregor Höpfner   +9 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Characterizing Efficacy of Alternative Media for Requirements Expression

Systems
Requirements are most commonly expressed in natural language, but alternative media can be employed. Previous research has established the viability of model diagrams and engineering drawings for requirements expression.
Jason Kolligs, Lawrence Dale Thomas
doaj   +1 more source

Quantitative Set-Based Design to Inform Design Teams

Applied Sciences, 2021
System designers, analysts, and engineers use various techniques to develop complex systems. A traditional design approach, point-based design (PBD), uses system decomposition and modeling, simulation, optimization, and analysis to find and compare ...
Eric Specking, Nicholas Shallcross, Gregory S. Parnell, Edward Pohl   +3 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source