Results 71 to 80 of about 235,815 (261)

Model Driven Architecture (MDA): Integration and Model Reuse for Open Source eLearning Platforms

E-learning and Education, 2005
Open Source (OS) community offers numerous eLearning platforms of both types: Learning Management Systems (LMS) and Learning Content Systems (LCS). General purpose OS intermediaries such as SourceForge, ObjectWeb, Apache or specialized intermediaries ...
Blasius Lofi Dewanto, Frank Bensberg, Heinz Lothar Grob   +2 more
doaj  

Model-Driven Architecture for Accelerating the Development of Tourism Applications

IEEE Access
The tourism sector has witnessed a significant shift towards digital transformation, with mobile and web applications becoming essential tools for enhancing tourist experiences.
Lahbib Naimi, Lamya Benaddi, Charaf Ouaddi, Adnane Souha, Hamza Abdelmalek, Abdeslam Jakimi   +5 more
doaj   +1 more source

The Model Transformation for Getting a UML Class Diagram from a Topological Functioning Model

Applied Computer Systems, 2015
The approach called Topological Functioning Modeling for Model Driven Architecture (TFM4MDA) uses a Topological Functioning Model (TFM) as a formal Computation Independent Model (CIM) within the Model Driven Architecture (MDA).
Solomencevs Arturs
doaj   +1 more source

Information Exchange between GIS and Geospatial ITS Databases Based on a Generic Model

ISPRS International Journal of Geo-Information, 2019
This study aims to improve interoperability between Geographic Information Systems (GIS) and geospatial databases for Intelligent Transport Systems (ITS). Road authorities maintain authoritative information for legal and safe navigation in GIS databases.
Knut Jetlund, Erling Onstein, Lizhen Huang   +2 more
doaj   +1 more source

Language Architecture: An Architecture Language for Model-Driven Engineering

Proceedings of the 5th International Conference on Model-Driven Engineering and Software Development, 2017
The increasing number of languages used to engineer complex systems causes challenges to the development and maintenance processes of these languages. In this paper, we reflect on our experience in developing real life complex cyber-physical systems by using MDE techniques and DSLs.
Niels Brouwers, Marc Hamilton, Ivan Kurtev, Yaping Luo   +3 more
openaire   +2 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

A Study of the Model Method Driven Architecture (MMDA) and Its Modeling Environment

SICE Journal of Control, Measurement, and System Integration, 2017
Model Driven Architecture (MDA) is a program development method designed for experts in modeling, but not in programming, and it has not been widely accepted yet. In this paper, we propose a new program development method that enables modeling experts to
Tadashi Kurata, Hiroshi Deguchi, Manabu Ichikawa   +2 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source