Results 81 to 90 of about 235,815 (261)

Comparing Transformation Possibilities of Topological Functioning Model and BPMN in the Context of Model Driven Architecture

Applied Computer Systems, 2016
The approach called “Topological Functioning Model for Software Engineering” (TFM4SE) applies the Topological Functioning Model (TFM) for modelling the business system in the context of Model Driven Architecture.
Solomencevs Artūrs
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Framework based on MDA and ontology for the representation and validation of components model

Revista Cubana de Ciencias Informáticas, 2014
Model Driven Architecture is one of the most prominent proposals in the area of software development, accepted by both the research community and software development industry.
Nemury Silega-Martínez, Danaysa Macías-Hernández, Yusnier Matos, Juan Pedro Febles   +3 more
doaj  

Model driven architecture and ontology development. [PDF]

, 2006
Defining a formal domain ontology is generally considered a useful, not to say necessary step in almost every software project. This is because software deals with ideas rather than with self-evident physical artefacts. However, this development step is hardly ever done, as ontologies rely on well-defined and semantically powerful AI concepts such as ...
Gašević, D., Đurić, Dragan, Devedžić, Vladan   +2 more
openaire  

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Network architecture and key technologies of intelligent optical networks driven by data and model

Dianxin kexue, 2022
With the expanding scale of the networks and the emerging applications of ultra-massive connection, ultra-high bandwidth and ultra-low delay, higher requirements are proposed for the utilization of optical transmission network resources and network ...
Zhiqun GU, Jiawei ZHANG, Yuefeng JI, Hao YU, Taleb Tarik   +4 more
doaj   +2 more sources

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Generating Accessible Webpages from Models

Computers
Despite significant efforts to promote web accessibility through the adoption of various standards and tools, the web remains inaccessible to many users.
Karla Ordoñez-Briceño, José R. Hilera, Luis De-Marcos, Rodrigo Saraguro-Bravo   +3 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source