Results 61 to 70 of about 9,651 (256)

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

A Model Driven Framework for Collaborative and Dynamic Design and Implementation of NoSQL-Oriented Data warehouses

Jordanian Journal of Computers and Information Technology
Nowadays, modernizing the data warehouse ecosystem is a key challenge in decision support systems. This modernization is crucial for ensuring scalability and meeting evolving business requirements, especially with the advent of big data.
Khadija Letrache, Mohammed Ramdani
doaj   +1 more source

FGF13 Deficiency Ameliorates Paclitaxel‐Induced Neuropathic Pain by Inhibiting VASH1‐Mediated Microtubule Detyrosination to Promote Mitophagy

Advanced Science, EarlyView.
FGF13 is upregulated in DRG neurons of PIPNP model mice. DRG neuron‐specific knockout of FGF13 ameliorates PIPNP symptoms. Mechanistically, FGF13 potentiates microtubule detyrosination by promoting VASH1 binding to microtubules. FGF13 knockout suppresses VASH1‐mediated microtubule detyrosination and promotes α‐tubulin tyrosination.
Yiming Dong, Yidan Wang, Simeng Lv, Zishan Dong, Kaixi Zhi, Xiuhua Guo, Xuyan Li, Ruoxi Yu, Yiyi Zhang, Siyuan Cheng, Chuan Wang   +10 more
wiley   +1 more source

Model Oriented Approach for Industrial Software Development

Моделирование и анализ информационных систем, 2015
The article considers the specifics of a model oriented approach to software development based on the usage of Model Driven Architecture (MDA), Model Driven Software Development (MDSD) and Model Driven Development (MDD) technologies.
P. D. Drobintsev, V. P. Kotlyarov, N. V. Voinov, I. V. Nikiforov   +3 more
doaj   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Una visión a la propuesta de Arquitectura Dirigida por Modelos

Revista UNIMAR, 2016
Este documento presenta un acercamiento a la iniciática Model Driven Architecture (MDA, Arquitectura Dirigida por Modelos) propuesta por Object Management Group (OMG). MDA separa la lógica de la aplicación del negocio.
Luis Muñoz, Guillermo Solarte, Douglas Hernández Heredia   +2 more
doaj  

A Model-Driven Architecture Solution for Multi-Platform Mobile App Development

Tehnički Glasnik
This paper presents a comprehensive Model Driven Architecture (MDA) approach for multi-platform mobile app development. We introduce a UML-based metamodel that encapsulates essential mobile app elements, including views, controls, resources, and events ...
Ayoub Korchi, Mohamed Karim Khachouch, Younes Lakhrisi   +2 more
doaj   +1 more source

A MDA Approach for avigational and User Perspectives

CLEI Electronic Journal, 2011
The study presented in this paper focuses on a navigational and user perspectives analysis of Web applications, highlighting some of their critical points for modeling.
Magalí González, Jorge Casariego, Juan Josee Bareiro, Luca Cernuzzi, Oscar Pastor   +4 more
doaj   +1 more source

Physics‐Informed Machine Learning for Sustainable Alloy Design: Toward a Recyclable Unified Q&P Steel

Advanced Science, EarlyView.
A physics‐informed property‐bridging framework links high‐throughput hardness screening to tensile performance in quenching and partitioning steels. By transferring metallurgically guided representations across properties, a single alloy composition is designed to achieve multiple strength grades through heat‐treatment tuning alone, offering a ...
Xiaolu Wei, Yong Li, Chenchong Wang, Lingyu Wang, Xiang Song, Keming Mao, Yu Zhang, Wei Xu   +7 more
wiley   +1 more source

SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition

Advanced Science, EarlyView.
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo, Liwei Zhang, Minlong Wang, Yanjin Du, Tianyu Zhang, Hao Chen, Jiazeng Sun, Yang Yu, Zude He, Jie An, Xiaoxu Zhang, Weilin Lin, Fazheng Ren, Pengjie Wang, Ping Liu   +14 more
wiley   +1 more source