Results 51 to 60 of about 352,837 (260)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Machines, 2023 Software development for robotic systems is traditionally performed based on simulations, manual code implementation, and testing. However, this software development approach can cause safety issues in some scenarios, including multiple robots sharing a ...
Metin Ozkan +3 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Model-Driven Engineering for Augmented Reality.
The Journal of Object Technology, 2023 Work partially supported by the Spanish Ministry of Science (PID2021-122270OB-I00) and the R&D programme of Madrid (P2018/TCS-4314). We would like to thank the reviewers for their useful comments, and the participants of the user study for their availability.
Campos López, Rubén +4 more
openaire +2 more sources
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
A brief introduction to model-driven engineering
Tecnura, 2014 La crisis del software es un concepto que comenzó a utilizarse en 1968, en la primera conferencia organizada por la Organización del Tratado del Atlántico Norte (OTAN) en el desarrollo de software.
Vicente García Díaz +5 more
doaj
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Model Driven Language Engineering
Electronic Notes in Theoretical Computer Science, 2003 AbstractThere is currently much interest in model driven approaches to software engineering. The basic idea is to make business, architecture and design models frst class artefacts that are not discarded once the code gets built, but rather can be exercised independently, be reconciled with each other and underlying implementations, and used to ...
openaire +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source