Results 61 to 70 of about 19,125,334 (286)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Engineering Science and Technology, an International Journal, 2021 Good domain-modeling enables an appropriate separation of concerns that improves quality properties in the simulation models, such as modifiability and maintainability.
María Julia Blas, Silvio Gonnet
doaj +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Model and quality driven embedded systems engineering
, 2009 The world of embedded systems is broad and diverse, addressing a wide variety of application domains. Although technologically, the situation for embedded systems is still quite fragmented, platform-based engineering, reference designs and maturing ...
Vicedo, Josetxo +6 more
core +1 more source
Semantic model driven engineering
, 2020 Semantic interoperability is a concern in the design and implementation of modern information systems. Whenever two systems communicate it is important that they share an adequate, common interpretation of any information transferred. Similarly, whenever data created or ac- quired in one context is used in another, it is important that the provenance ...
openaire +3 more sources
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Model Driven Language Engineering
Electronic Notes in Theoretical Computer Science, 2003 AbstractThere is currently much interest in model driven approaches to software engineering. The basic idea is to make business, architecture and design models frst class artefacts that are not discarded once the code gets built, but rather can be exercised independently, be reconciled with each other and underlying implementations, and used to ...
openaire +1 more source
Evaluating Quality in Model-Driven Engineering [PDF]
International Workshop on Modeling in Software Engineering (MISE'07: ICSE Workshop 2007), 2007 In model-driven engineering (MDE), models are the prime artifacts, and developing high-quality systems depends on developing high-quality models and performing transformations that preserve quality or even improve it. This paper presents quality goals in MDE and states that the quality of models is affected by the quality of modeling languages, tools ...
Mohagheghi, Parastoo, Aagedal, Jan
openaire +3 more sources