Results 71 to 80 of about 1,764,289 (298)
Engineering Science and Technology, an International Journal, 2021 Good domain-modeling enables an appropriate separation of concerns that improves quality properties in the simulation models, such as modifiability and maintainability.
María Julia Blas, Silvio Gonnet
doaj +1 more source
Feasibility of EPC to BPEL Model Transformations Based on Ontology and Patterns [PDF]
, 2010 Model-Driven Engineering holds the promise of transforming\ud business models into code automatically. This requires the concept of\ud model transformation.
Eckartz, Silja M. +2 more
core +3 more sources
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Semantic model driven engineering
, 2020 Semantic interoperability is a concern in the design and implementation of modern information systems. Whenever two systems communicate it is important that they share an adequate, common interpretation of any information transferred. Similarly, whenever data created or ac- quired in one context is used in another, it is important that the provenance ...
openaire +3 more sources
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
An Experiment in Model Driven Architecture for e-Enterprise Systems [PDF]
, 2002 OMG's Model Driven Architecture demonstrates how a system's specification model can be used within the process of creating supporting software implementations.
Kent, Stuart, Smith, Robert P.
core
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
A methodological proposal and tool support for the HL7 standards compliance in the development of health information systems [PDF]
, 2017 Health information systems are increasingly complex, and their development is presented as a challenge for software development companies offering quality, maintainable and interoperable products.
Domínguez-Mayo, F.J +7 more
core
Model Driven Language Engineering
Electronic Notes in Theoretical Computer Science, 2003 AbstractThere is currently much interest in model driven approaches to software engineering. The basic idea is to make business, architecture and design models frst class artefacts that are not discarded once the code gets built, but rather can be exercised independently, be reconciled with each other and underlying implementations, and used to ...
openaire +1 more source