Results 71 to 80 of about 19,125,334 (286)
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Agile model-driven re-engineering [PDF]
Innovations in Systems and Software EngineeringAbstractIn this paper we describe an Agile model-driven engineering (MDE) approach, AMDRE, for the re-engineering of legacy systems. The objective is to support the reuse of business-critical functionality from such systems and the porting of legacy code to modernised platforms, together with technical debt reduction to improve the system ...
Kevin Lano +3 more
openaire +2 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
A formal foundation for transformations in model driven engineering
Journal of Computer Science and Technology, 2008 In the MDE (Model Driven Engineering) paradigm, models are thought to be the primary conductors in all software development aspects. A PIM (Platform Independent Model) is transformed into one or more PSMs (Platform Specific Model); hence, a specific PSM ...
Roxana Silvia Giandini
doaj
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
A Multi-Agent System Architecture for Sensor Networks
Sensors, 2009 The design of the control systems for sensor networks presents important challenges. Besides the traditional problems about how to process the sensor data to obtain the target information, engineers need to consider additional aspects such as the ...
María Guijarro +2 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Agile Development of PHP Websites: A Model-Aware Approach
Complex Systems Informatics and Modeling Quarterly, 2020 The Design Science research method was hereby employed to develop an artifact that demonstrates the experimental “model-aware” software engineering methodology in the context of PHP Web development – a “low code” development approach with code templates ...
Carmen Ioana Gog
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source