Results 91 to 100 of about 19,125,334 (286)

The microbiome in human skin aging

open access: yesFEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana   +3 more
wiley   +1 more source

Challenging Models: Formalizing Quests in Gamified Systems for Behavioral Change

open access: yes, 2023
Tasks performed by users in exchange for some reward, also known as quests or challenges, are one of the essential elements found in gamified systems, including systems for behavioral change.
Bonetti, Federico   +3 more
core   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

open access: yesFEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Scalability in Model Driven Engineering

open access: yes, 2013
As Model Driven Engineering (MDE) is increasingly applied to larger and more complex systems, the current generation of modelling and model management technologies are being pushed to their limits in terms of capacity and efficiency.
Di Ruscio, Davide   +5 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

MDWEnet: a practical approach to achieving interoperability of model-driven web engineering methods [PDF]

open access: yes, 2007
Current model-driven Web Engineering approaches (such as OO-H, UWE or WebML) provide a set of methods and supporting tools for a systematic design and development of Web applications.
Rivera, José E.   +36 more
core  

Coordinating REST interactions in service choreographies using blockchain

open access: yesBlockchain: Research and Applications
In Service Oriented Computing (SOC), different services interact and exchange information to reach specific objectives. To model interorganizational SOC systems, choreography modeling languages have emerged to represent the distributed coordination among
Francesco Donini   +3 more
doaj   +1 more source

Model-driven engineering city spaces via bidirectional model transformations. [PDF]

open access: yesSoftw Syst Model, 2021
Visconti E, Tsigkanos C, Hu Z, Ghezzi C.
europepmc   +1 more source

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