Results 91 to 100 of about 1,764,289 (298)
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Rapid Prototyping of Multi-Functional Battery Energy Storage System Applications
Battery Energy Storage Systems (BESS) are starting to play an important role in today’s power distribution networks. They provide a manifold of services for fulfilling demands and requests from diverse stakeholders, such as distribution system operators,
Claudia Zanabria +3 more
doaj +1 more source
Diversity and complexity in neural organoids
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Quality Issues on Model-Driven Web Engineering Methodologies [PDF]
Nowadays, there are several development methodologies in the field of model-driven web engineering (MDWE) which involve different levels of modeldriven architecture (MDA): CIM, PIM, PSM, or code. Attending to the high number of available methodologies,
Domínguez Mayo, Francisco José +2 more
core +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Model Driven Engineering with Capella and AADL [PDF]
The development of real time embedded equipments is a challenging task that requires the elaboration of multiple models in several domains, notably system, electronics and software, spanning a large spectrum of multiple abstraction levels and viewpoints:
Gaufillet, Pierre +3 more
core +1 more source
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Systematic Reviews in Model-Driven Engineering: A Tertiary study
To cope with growing complexity of software-intensive systems, model-driven engineering (MDE) has become a widely used approach in the industry by providing many (potential) benefits with different purposes. Although there has been an increasing interest
Deniz Akdur, Onur Demirörs
doaj
Analysis of the scientific production of the Spanish Software Engineering Community [PDF]
Our group has been working on a report for the Spanish Society of Software Engineering and Software Development Technologies (SISTEDES) to provide a general overview of the Spanish scientific production and its contributions worldwide in the field of ...
Burgueño, Loli +2 more
core

