Results 101 to 110 of about 19,125,334 (286)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Software evolution in model-driven product line engineering [PDF]
, 2012 New requirements and technology changes lead to continuous changes of the assets comprising a software product line. Since the product line represents a large number of potential products (or already deployed products) in a given domain, managing these
Abrahao Gonzales, Silvia Mara +3 more
core
Frontiers in Computer ScienceSince its emergence in 2009, DevOps has significantly advanced software development. Numerous studies have explored the evolution of DevOps and its related methodologies.
Uldis Karlovs-Karlovskis +4 more
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Model Driven Grant Proposal Engineering
, 2014 We demonstrate the application of Model Driven Engineering techniques to support the development of research grant proposals. In particular, we report on using model-to-text transformation and model validation to enhance productivity and consistency in research proposal writing, and present unanticipated opportunities that were revealed after ...
Kolovos, Dimitrios S. +3 more
openaire +2 more sources
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Semantic model-driven development of web service architectures. [PDF]
, 2008 Building service-based architectures has become a major area of interest since the advent of Web services. Modelling these architectures is a central activity. Model-driven development is a recent approach to developing software systems based on the idea
Claus Pahl, Pahl, Claus
core +2 more sources
Model Driven Language Engineering with Kermeta
, 2011 In many domains such as telecom, aerospace and automotive industries, engineers rely on Domain Specific Modeling Languages (DSML) to solve the complex issues of engineering safety critical software. Traditional Language Engineering starts with the grammar of a language to produce a variety of tools for processing programs expressed in this language ...
Jézéquel, Jean-Marc +2 more
openaire +3 more sources
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source