Results 81 to 90 of about 19,125,334 (286)
Systematic Reviews in Model-Driven Engineering: A Tertiary study
Havacılık ve Uzay Teknolojileri Dergisi, 2020 To cope with growing complexity of software-intensive systems, model-driven engineering (MDE) has become a widely used approach in the industry by providing many (potential) benefits with different purposes. Although there has been an increasing interest
Deniz Akdur, Onur Demirörs
doaj
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Foundations of Model (Driven) (Reverse) Engineering: Models -- Episode I: Stories of the Fidus Papyrus and of the Solarus [PDF]
, 2004 Model Driven Engineering (MDE) received a lot of attention in the last years, both from academia and industry. However, there is still a debate on which basic concepts form the foundation of MDE.
Jean-Marie Favre, Favre, Jean-Marie
core +1 more source
Rapid Prototyping of Multi-Functional Battery Energy Storage System Applications
Applied Sciences, 2018 Battery Energy Storage Systems (BESS) are starting to play an important role in today’s power distribution networks. They provide a manifold of services for fulfilling demands and requests from diverse stakeholders, such as distribution system operators,
Claudia Zanabria +3 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Meadmore Model Engineering Company.
, 1920 Cover subtitle: Scale models of all varieties.; Electronic reproduction. Canberra, A.C.T.
Meadmore Model Engineering Co.
core
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Distributed embedded control systems design with verification support
Моделирование и анализ информационных систем, 2010 We consider a problem of integrating a formal method of verification (model checking) into the process of designing complex distributed software systems to improve the quality of software. We use an approach based on the Model-Driven Engineering.
I. V. Shoshmina
doaj