Results 81 to 90 of about 1,202,565 (290)
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Model averaging with causal effects for partially linear models
AIMS MathematicsTreatment effects with heterogeneity and heteroskedasticity are widely studied and applied in many fields, such as statistics and econometrics. The conditional average treatment effect provides an excellent measure of the heterogeneous treatment effect ...
Xiaowei Zhang, Junliang Li
doaj +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Model Averaging for Accelerated Failure Time Models with Missing Censoring Indicators
MathematicsModel averaging has become a crucial statistical methodology, especially in situations where numerous models vie to elucidate a phenomenon. Over the past two decades, there has been substantial advancement in the theory of model averaging. However, a gap
Longbiao Liao, Jinghao Liu
doaj +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Journal of Integrative AgricultureFaced with increasing global soil degradation, spatially explicit data on cropland soil organic matter (SOM) provides crucial data for soil carbon pool accounting, cropland quality assessment and the formulation of effective management policies.
Xianglin Zhang +7 more
doaj +1 more source
Global Climate Model Ensemble Approaches for Future Projections of Atmospheric Rivers
Earth's Future, 2019 Atmospheric rivers (ARs) are narrow jets of integrated water vapor transport that are important for the global water cycle and also have large impacts on local weather and regional hydrology.
E.C. Massoud +3 more
doaj +1 more source
Effect of non-polynomial input to a switching circuit [PDF]
, 2001 In this paper, the validity of the state-space averaging method is analyzed. We assume that the state-space piecewise method is an exact model for a fast switching circuit.
Ling, Wing-Kuen, Tam, Peter Kwong-Shun
core
Model averaging has gained significant attention in recent years due to its ability of fusing information from different models. The critical challenge in frequentist model averaging is the choice of weight vector. The bootstrap method, known for its favorable properties, presents a new solution.
Song, Minghui +2 more
openaire +2 more sources