Results 121 to 130 of about 775,103 (306)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Application of Model-based Systems Engineering [PDF]

, 2009
The Objective of this Project was to Develop a System Engineering (SE) Methodology for Creating Complex, Supportable System Architectures that: – Utilize a Model Based Systems Engineering (MBSE) approach – Integrate Requirements Traceability – Implement ...
Green, John Mike
core  

Set-based design of mechanical systems with design robustness integrated [PDF]

, 2014
This paper presents a method for parameter design of mechanical products based on a set-based approach. Set-based concurrent engineering emphasises on designing in a multi-stakeholder environment with concurrent involvement of the stakeholders in the ...
DANTAN, Jean-Yves, Bigot, Régis, QURESHI, Ahmed Jawad, BRUYERE, Jérôme   +3 more
core   +2 more sources

Transdisciplinary model-based systems engineering in the development of the Ruminant Farm Systems model

Frontiers in Sustainability
This study adopts a transdisciplinary model-based systems engineering (MBSE) approach to support the development of the Ruminant Farm Systems (RuFaS) model, an advanced on-farm decision support tool.
Haowen Hu, Clifford A. Whitcomb, Thomas E. Ploetz, Kristan F. Reed, Kristan F. Reed   +4 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

International Conference on Industry, Engineering, and Management Systems 2015 [PDF]

, 2015
Published in SOAR: Shocker Open Access Repository by Wichita State University Libraries Technical Services, May 2022.The IEMS'15 conference committee: Nael Aly (Conference Co-Chair); Ahmad Elshennawy (Conference Co-Chair); Alfred Petrosky (Program Chair);
International Conference on Industry, Engineering, and Management Systems
core   +1 more source

Optimizing additive manufacturing workflows using model-based systems engineering

Results in Engineering
Additive Manufacturing (AM) is a transformative technology enabling the production of complex geometries with reduced waste and lead times. However, optimizing AM workflows involves addressing challenges such as design validation, process parameters, and
Mohamed Amine Daoud, Khadija Bekkay Haouari, Meriem Hayani Mechkouri, Amine Ennawaoui, Hicham El hadraoui, Ilias Naser, Mustapha Ouardouz, Kamal Reklaoui   +7 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Interface Management in Concurrent Engineering Facilities for Systems and Service Systems Engineering: A Model-based Approach [PDF]

, 2014
Concurrent engineering facilities (CEFs) are successfully used in the aeropsace sector to design systems and services that that fulfill the requirements.
Schaus, Volker, Gianni, D, Gerndt, A, Schaus, V, De Simone, Pierluigi, Simone, P., Lisi, M, Gianni, Daniele, D'Ambrogio, A, Gerndt, Andreas, Simone, P, Lisi, Marco, D'Ambrogio, Andrea   +12 more
core  

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source