Results 111 to 120 of about 775,103 (306)
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
SystemsThis paper proposes a formal method and associated techniques for completing the ISO/IEC/IEEE Standard 15288 technical process 6.4.2—Stakeholder Needs and Requirements definition within the 15288-SysML Grid framework.
Kevin MacG. Adams +2 more
doaj +1 more source
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
Requirements engineering for business workflow systems: a scenario-based approach [PDF]
, 2001 Workflow implementations require a deep understanding of business and human cooperation. Several approaches have been proposed to address this need for understanding, but largely in a descriptive way. Attempts to use them in software development have had
Strassl, Johann Gerhard, Strassl, J.G.
core
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Approach for model-based test specifications in the context of space engineering [PDF]
The increasing complexity and interdisciplinarity of space projects re-quire a formalization and digitalization of the development process. Model-based Systems Engineering offers an approach to formally capture the systems engi-neering methodology and ...
Brahm, Michael +3 more
core
An Advanced Computational Approach to System of Systems Analysis & Architecting Using Agent-Based Behavioral Model [PDF]
, 2012 The goal of this research is to model the evolution of the architecture of an acknowledged Systems of Systems (SoS) that accounts for the ability and willingness of constituent systems to support the SoS capability development.
Rebovich, George +7 more
core
A Critique of the Authoritative Source of Truth Concept in Model-Based Systems Engineering [PDF]
693697With the ongoing adoption of Model-Based Systems Engineering (MBSE) as a best practice in several domains there are ongoing efforts to improve the maturity of MBSE methods. In the vision for MBSE several organizations and actors foresee a landscape
Zimmermann, Thomas, Cederbladh, Johan
core +1 more source
Nanomedicine: A systems engineering approach [PDF]
, 2009 This book offers a fundamental and comprehensive overview of nanomedicine from a systems engineering perspective, making it the first book in the field of quantitative nanomedicine based on systems theory.
Zhang, Mingjun, Xi, Ning
core +1 more source
SystemsA holistic approach to decision-making in modern energy systems is vital due to their increase in complexity and interconnectedness. However, decision makers often rely on narrowly-focused strategies, such as economic assessments, for energy system ...
Svetlana Lawrence, Daniel R. Herber
doaj +1 more source