Results 101 to 110 of about 775,103 (306)

Using a Metadata Approach to Extend the Functional Resonance Analysis Method to Model Quantitatively, Emergent Behaviours in Complex Systems

Systems
In an increasingly complex world there is a real, urgent need for methodologies to enable engineers to model complex sociotechnical systems, as these now seem to describe the majority of systems in use today.
Rees Hill, David Slater
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

V-Model Role Engineering [PDF]

The paper focuses on role engineering which is an important topic in the development of access control system, particularly when considering Role Based Access Control – RBAC models.
Radu CONSTANTINESCU
core  

Enhancing model-based systems engineering with the Lifecycle Modeling Language [PDF]

, 2016
As systems become more complex, the systems engineering community must find new and more efficient ways of dealing with complexity throughout the system's lifecycle.
Vaneman, Warren K.
core  

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

GenAI for Simulation Model in Model-Based Systems Engineering

CoRR
This work has been submitted to the IEEE for possible ...
Lin Zhang 0009, Yuteng Zhang, Dusit Niyato, Lei Ren 0001, Pengfei Gu, Zhen Chen 0043, Yuanjun Laili, Wentong Cai 0001, Agostino G. Bruzzone   +8 more
openaire   +2 more sources

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Systems practice in engineering: reflections on doctoral level systems supervision [PDF]

, 2011
The Industrial Doctorate Centre (IDC) in Systems, a collaboration between the University of Bristol and the University of Bath, offers an Engineering Doctorate (EngD) in Systems Programme which is aimed at high-calibre engineers from graduate level to ...
Yearworth, M, Yearworth, Mike
core  

A Vision of Collaborative Verification-Driven Engineering of Hybrid Systems [PDF]

, 2013
Hybrid systems with both discrete and continuous dynamics are an important model for real-world physical systems. The key challenge is how to ensure their correct functioning w.r.t. safety requirements.
Stefan Mitsch, Grant Olney Passmore (5415671), Mitsch, Stefan, Platzer, André, Grant Olney Passmore, Andre Platzer (5363771), Passmore, Grant Olney, Stefan Mitsch (5415674), André Platzer   +8 more
core   +1 more source

Seamless Function-Oriented Mechanical System Architectures and Models

Eng
One major challenge of today’s product development is to master the constantly increasing product complexity driven by the interactions between different disciplines, like mechanical, electrical and software engineering.
Christian Wyrwich, Kathrin Boelsen, Georg Jacobs, Thilo Zerwas, Gregor Höpfner, Christian Konrad, Joerg Berroth   +6 more
doaj   +1 more source