Results 81 to 90 of about 775,103 (306)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Towards more effective testing of communications-critical large scale systems [PDF]

, 2014
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.A publication based on the research from this thesis has been published and can be cited as Nabulsi, MA and Hierons, RM (2014), A new test framework for ...
Nabulsi, Mohammad
core  

Effectiveness Evaluation Method Using System of Systems Architecture Description of Aircraft Health Management in Aircraft Maintenance Program

International Journal of Prognostics and Health Management
This study proposes a system modeling method for aircraft maintenance program development that adopts condition-based maintenance using aircraft health management (AHM) based on a systems engineering approach, which considers AHM as a system of systems ...
Takuro Koizumi, Nozomu Kogiso
doaj   +1 more source

Improving the Model-Based Systems Engineering Process [PDF]

, 2022
AbstractModern embedded software systems are becoming more and more complex. Engineering embedded systems raise specific challenges that are rarely present in other software engineering disciplines due to the systems’ steady interactions with their environment.
openaire   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Model and Quality Driven Embedded Systems Engineering [PDF]

, 2009
The world of embedded systems is broad and diverse, addressing a wide variety of application domains. Although technologically, the situation for embedded systems is still quite fragmented, platform-based engineering, reference designs and maturing ...
Vicedo, Josetxo, Tiensyrjä, Kari, Noguero, Adrian, Campos, Sergio, Ovaska, Eila, Pataricza, András, Balogh, András   +6 more
core  

Open-Source Data Formalization through Model-Based Systems Engineering for Concurrent Preliminary Design of CubeSats

Aerospace
Market trends in the space sector suggest a notable increase in satellite operations and market value for the coming decade. In parallel, there has been a shift in the industrial and academic sectors from traditional Document-Based System Engineering to ...
Giacomo Luccisano, Sophia Salas Cordero, Thibault Gateau, Nicole Viola   +3 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Model-based Interface Specification for Systems Integration in Systems of Systems Engineering [PDF]

, 2012
The key to enable systems integration is that systems inter-communications are accurately and unambiguously specified. In line with ongoing Model-based Systems Engineering (MBSE) initiatives aiming to support systems engineering activities by means of ...
Gianni, D, Daniele Gianni, Andrea D'Ambrogio, Michele Luglio, Luglio, M, D'AMBROGIO, ANDREA, D’Ambrogio, A, Lisi, M, LUGLIO, MICHELE, Pierluigi De Simone, Marco Lisi, De Simone, P   +11 more
core   +1 more source

Product Cost Calculation in Model-Based Systems Engineering

Systems
In product development, costs play a major role in making design decisions. As such, it is desirable to have this information as early as possible in the product development process (PDP).
Georg Hartmann, Thilo Zerwas, Lisa Domröse, Kathrin Boelsen, Christian Hilger, Simon Schnürer   +5 more
doaj   +1 more source