Results 61 to 70 of about 775,103 (306)
Application of model based systems engineering methods to development of combat system architectures [PDF]
, 2009 Navy acquisition activities frequently produce combat system architectures based on existing systems rather than stakeholder requirements. This approach limits software component reuse which, in turn, limits potential application to other platforms ...
Hoang, Tuyen +26 more
core
Reuse in Systems Engineering [PDF]
, 2010 Reuse in systems engineering is a frequent but poorly understood phenomenon. Nevertheless, it has a significant impact on system development and on estimating the appropriate amount of systems engineering effort with models like the Constructive Systems ...
Jared Fortune +5 more
core +1 more source
Applied SciencesThe use and importance of complex software-intensive systems are growing. As they are used in a wider range of situations in which dependability must be ensured, the reliability of the systems and of their components needs to be addressed throughout ...
Juan Manuel Morote +4 more
doaj +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
SystemsThe development of patient-specific medical systems poses challenges for requirements engineering and their traceable integration into system models, as regulatory frameworks require transparent and traceable links between stakeholder needs and product ...
Franziska Wieja +4 more
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
How does one Model Appropriately in Systems Engineering? An Initial Conceptual Model Framing Model Appropriateness [PDF]
930934Appropriateness of models through modelling languages, tools, and methods is at the core of systems modelling. A concrete example is that useful abstraction depends on the contextual case of modelling purpose and need.
Cederbladh, Johan, Zimmermann, Thomas C.
core +3 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source