Results 71 to 80 of about 775,103 (306)

Mapping customer needs to engineering characteristics: an aerospace perspective for conceptual design [PDF]

open access: yes, 2014
Designing complex engineering systems, such as an aircraft or an aero-engine, is immensely challenging. Formal Systems Engineering (SE) practices are widely used in the aerospace industry throughout the overall design process to minimise the overall ...
Eres, M.H.   +8 more
core   +2 more sources

Adaptable MBSE Problem Definition with ARMADE: Perspectives from Firefighting and AAM SoS Environments

open access: yesEngineering Proceedings
Model-based systems engineering (MBSE) offers significant advantages over traditional document-based approaches, particularly in improving the clarity, traceability, and efficiency of requirements engineering (RE).
Adrian Chojnacki   +4 more
doaj   +1 more source

Model-based simulation systems engineering

open access: yes, 2018
Synergien spielen eine entscheidende Rolle in der Entwicklung der Simulationsdisziplin. Der Beitrag des Fachbereichs Systems Engineering zur Simulation besteht in der Einführung von Methoden, die das Engineering von Simulationen speziell für große und komplexe Systeme verbessern.
openaire   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Quality-aware model-driven service engineering [PDF]

open access: yes, 2008
Service engineering and service-oriented architecture as an integration and platform technology is a recent approach to software systems integration.
Boskovic, Marko   +3 more
core  

An Activity-Based Model of Concurrent Engineering System [PDF]

open access: yes, 2002
The Concurrent Engineering (CE) concept is an advanced organizational concept based on idea of parallel/simultaneous and concurrent processing of the requirements of different business/enterprise’s functions such as marketing, CAD, CAM, PPC, manufacturing, etc.
Goran D. Putnik   +1 more
openaire   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

A conceptual system design and managerial complexity competency model [PDF]

open access: yes, 2013
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Complex adaptive systems are usually difficult to design and control.
Amaechi, Austin Oguejiofor
core  

Engineering a Safer World [PDF]

open access: yes, 2012
A new approach to safety, based on systems thinking, that is more effective, less costly, and easier to use than current techniques. Engineering has experienced a technological revolution, but the basic engineering techniques applied in safety and ...
Leveson, Nancy G.
core   +1 more source

Engineering Systems with Standards and Digital Models: Development of a 15288-SysML Grid

open access: yesSystems
The paradigm shift that has spurred the fourth industrial revolution, in what is termed Industry 4.0, has ushered in the need to adopt digital technologies throughout the worldwide industrial base to support system design efforts. The adoption of digital
Kevin MacG. Adams   +2 more
doaj   +1 more source

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