Results 61 to 70 of about 587,913 (313)
IntCal04 terrestrial radiocarbon age calibration, 0-26 cal kyr BP [PDF]
, 2004 A new calibration curve for the conversion of radiocarbon ages to calibrated (cal) ages has been constructed and internationally ratified to replace ImCal98, which extended from 0-24 cal kyr BP (Before Present, 0 cal BP = AD 1950).Buck, C. E., Beck, J. Warren,, McCormac, G., Bertrand, C.J.H., Reimer, Ron W.,, Bertrand, Chanda J.H.,, Bertrand, Chanda J. H., Stuiver, Minze,, Guilderson, T., Beck, J. W., Blackwell, Pg, Reimer, R. W., Manning, Sturt W., Fairbanks, R. G., Remmele, S, Hogg, Alan G.,, Fairbanks, Richard G.,, Fairbanks, R., Kromer, B, Buck, C.E., Weyhenmeyer, Constanze E., Beck, J.W., Bard, Edouard, van der Plicht, Johannes, Baillie, Mike G.L.,, Weyhenmeyer, C. E., Ramsey, C.B., Bard, E., McCormac, Gerry,, Damon, P.E., Fairbanks, Rg, Kromer, Bernd, Hughen, K.A., Damon, Paul E., Ramsey, C., Hog, Ag, McCormac, Gerry, Damon, P., Manning, S., Hughen, K. A., Fairbanks, R.G., Bertrand, C, Stuiver, M., Plicht, Johannes van der, Reimer, Paula J., Southon, Jr, Damon, Pe, Guilderson, Tp, Baillie, Mike G.L., Edwards, R. L., Buck, Caitlin E., Blackwell, P.G., Bertrand, Chanda J.H., Remmele, Sabine,, Talamo, S, Talamo, Sahra, Cutler, K. B., Plicht, Johannes van der,, Ramsey, C. B., Talamo, S. ; https://orcid.org/, Taylor, F.W.,, Bronk Ramsey, C, Hughen, Konrad A., Weyhenmeyer, Ce, Reimer, P., Blackwell, Paul G., Ramsey, Christopher Bronk, Taylor, Fw, Friedrich, Michael,, Buck, C., Bayliss, A, Blackwell, Paul G.,, Hogg, Alan G., Blackwell, P. G., Stuiver, Minze, Bayliss, Alex,, Plicht, J,, Taylor, F.W., Plicht, J., Cutler, Kb, Burr, G., Taylor, F., Reimer, Paula J.,, Southon, J., van der Plicht, J., Hogg, A.G., Weyhenmeyer, Constanze E.,, Reimer, Paula; id_orcid, Hughen, Konrad A.,, Baillie, Mgl, Edwards, R. Lawrence, Guilderson, Thomas P.,, Burr, George S.,, Burr, G.S., Weyhenmeyer, C.E., Weyhenmeyer, C., Southon, John R.,, Bertrand, C. J. H., Burr, G. S., Reimer, P. J., Guilderson, T. P., Reimer, Ron, Talamo, Sahra,, Edwards, R., Stuiver, M, Remmele, Sabine, Edwards, R. Lawrence,, Hughen, K., Southon, J.R., Beck, Jw, Southon, John R., Reimer, R., Guilderson, Thomas P., Baillie, M. G. L., Bayliss, A., Reimer, Pj, Manning, S, Cutler, K., Bard, E, Baillie, M., Remmele, S., Edwards, R.L., Bard, Edouard,, Baillie, Mike G. L., Hogg, A. G., Reimer, Ron W., Manning, Sturt,, Manning, Sturt, Bronk Ramsey, Christopher,, Buck, Ce, Plicht, J, van Der, Bayliss, Alex, Bertrand, C., Blackwell, P., Buck, Caitlin E.,, Cutler, Kirsten B.,, Friedrich, M., Burr, George S., Cutler, Kirsten B., Damon, Paul E.,, Burr, Gs, Damon, P. E., Friedrich, Michael, Talamo, S., Reimer, Rw, Kromer, Bernd,, Mccormac, G, Baillie, Michael, Hogg, A., Guilderson, T.P., Beck, J., Kromer, B., Taylor, F. W., Hughen, Ka, Edwards, Rl, Culter, K.B., Beck, J. Warren, Friedrich, M, Bronk Ramsey, Christopher, Fairbanks, Richard G., Southon, J. R. +160 morecore +1 more sourceInterrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne +61 morewiley +1 more sourceCalibration of Continual Learning Models
2024 IEEE/CVF Conference on Computer Vision and Pattern Recognition Workshops (CVPRW)Continual Learning (CL) focuses on maximizing the predictive performance of a model across a non-stationary stream of data. Unfortunately, CL models tend to forget previous knowledge, thus often underperforming when compared with an offline model trained jointly on the entire data stream.Li, Lanpei, Piccoli, Elia, Cossu, Andrea, Bacciu, Davide, Lomonaco, Vincenzo +4 moreopenaire +5 more sourcesOn the calibration of compartmental epidemiological models
CoRR, 2023 Epidemiological compartmental models are useful for understanding infectious disease propagation and directing public health policy decisions. Calibration of these models is an important step in offering accurate forecasts of disease dynamics and the effectiveness of interventions.Nikunj Gupta, Anh L. Mai, Azza Abouzied, Dennis E. Shasha +3 moreopenaire +2 more sourcesInterpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo +7 morewiley +1 more sourceClinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski +12 morewiley +1 more sourcePatient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych +12 morewiley +1 more sourceRaman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans +3 morewiley +1 more sourceMycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci +7 morewiley +1 more source
