Results 41 to 50 of about 226,838 (267)

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

Optimized AlexNet Pruning for Edge-Based Medical Diagnostics

IEEE Access
Medical diagnostics demand rapid and accurate disease detection to ensure timely treatment, directly impacting human lives. Deep neural networks (DNNs) have shown unparalleled success in medical applications, surpassing traditional methods.
Yasser A. Amer, Hassan I. Saleh, Omar A. Nasr   +2 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Hyper-Compression: Model Compression via Hyperfunction

IEEE Transactions on Pattern Analysis and Machine Intelligence
The rapid growth of large models' size has far outpaced that of computing resources. To bridge this gap, encouraged by the parsimonious relationship between genotype and phenotype in the brain's growth and development, we propose the so-called Hyper-Compression that turns the model compression into the issue of parameter representation via a ...
Feng-Lei Fan, Juntong Fan, Dayang Wang, Jingbo Zhang, Zelin Dong, Shijun Zhang, Ge Wang, Tieyong Zeng   +7 more
openaire   +3 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Sub 4-bit Power-of-Two-Based Mixed-Precision Quantization for Efficient LLM Compression and Acceleration

IEEE Access
While Large Language Models (LLMs) have demonstrated remarkable performance, their deployment on resource-constrained edge devices is hindered by their immense size.
Han Cho, Apurba Prasad Padhy, Fernando Camacho, Saibal Mukhopadhyay   +3 more
doaj   +1 more source

On the Compression of Natural Language Models

CoRR, 2021
Deep neural networks are effective feature extractors but they are prohibitively large for deployment scenarios. Due to the huge number of parameters, interpretability of parameters in different layers is not straight-forward. This is why neural networks are sometimes considered black boxes.
openaire   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Research on Lightweight Open-Pit Mine Driving Obstacle Detection Algorithm Based on Improved YOLOv8s

Applied Sciences
The road environment of open-pit mines is complex and unstructured. Unmanned construction machinery driving faces huge challenges. Improving the accuracy and speed of obstacle detection during driving is of great significance to ensuring the safety of ...
Bo Xu, Wubin Xu, Bing Li, Hanwen Zhang, Yuanbin Xiao, Weixin Zhou   +5 more
doaj   +1 more source