Results 61 to 70 of about 914,662 (294)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Vertical facing panel-joint gap analysis for steel-seinforced soil walls [PDF]

, 2016
This paper reports the results of a numerical parametric study focused on the prediction of vertical load distribution and vertical gap compression between precast concrete facing panel units in steel-reinforced soil walls ranging in height from 6 to 24 ...
Bathurst, Richard, Josa Garcia-Tornel, Alejandro, Lloret Morancho, Antonio, Puig Damians, Ivan   +3 more
core   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Sub 4-bit Power-of-Two-Based Mixed-Precision Quantization for Efficient LLM Compression and Acceleration

IEEE Access
While Large Language Models (LLMs) have demonstrated remarkable performance, their deployment on resource-constrained edge devices is hindered by their immense size.
Han Cho, Apurba Prasad Padhy, Fernando Camacho, Saibal Mukhopadhyay   +3 more
doaj   +1 more source

When Compression Meets Model Compression: Memory-Efficient Double Compression for Large Language Models

Findings of the Association for Computational Linguistics: EMNLP 2024
Large language models (LLMs) exhibit excellent performance in various tasks. However, the memory requirements of LLMs present a great challenge when deploying on memory-limited devices, even for quantized LLMs. This paper introduces a framework to compress LLM after quantization further, achieving about 2.2x compression ratio.
Wang, Weilan, Mao, Yu, Tang, Dongdong, Du, Hongchao, Guan, Nan, Xue, Chun Jason   +5 more
openaire   +2 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Research on Lightweight Open-Pit Mine Driving Obstacle Detection Algorithm Based on Improved YOLOv8s

Applied Sciences
The road environment of open-pit mines is complex and unstructured. Unmanned construction machinery driving faces huge challenges. Improving the accuracy and speed of obstacle detection during driving is of great significance to ensuring the safety of ...
Bo Xu, Wubin Xu, Bing Li, Hanwen Zhang, Yuanbin Xiao, Weixin Zhou   +5 more
doaj   +1 more source

A survey of model compression for deep neural networks

工程科学学报, 2019
In recent years, deep neural networks (DNN) have attracted increasing attention because of their excellent performance in computer vision and natural language processing.
LI Jiang-yun, ZHAO Yi-kai, XUE Zhuo-er, CAI Zheng, LI Qing   +4 more
doaj   +1 more source

Modelling the rapid spherical compression of isotropic turbulence

, 1991
Rapid distortion analysis is used to modify the form of the closure model for the dissipation rate of the turbulent kinetic energy. The modification is such that the evolution of the dissipation rate during a rapid compression is predicted exactly; good ...
Coleman, G.N., Mansour, N.N.
core   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source