Results 101 to 110 of about 20,578 (261)
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
State of arbitrary complexity and Model Driven Architecture in the software development in Cuba
Revista Cubana de Ciencias Informáticas, 2014 Informatic systems play an important role in the society because are used in the majority of fields. The community of software researchers and developers devotes substantial efforts to determine how software systems can increasingly improve the ...
Nemury Silega +3 more
doaj
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Distribution pattern-driven development of service architectures [PDF]
, 2009 Distributed systems are being constructed by composing a number of discrete components. This practice is particularly prevalent within the Web service domain in the form of service process orchestration and choreography.
Barrett,Ronan +3 more
core +1 more source
Usability evaluation of the domain specific language for spatial simulation scenarios
Cogent Engineering, 2018 This article presents the results of a usability evaluation initiative conducted on the Domain Specific Language for Spatial Simulation Scenarios (short name DSL3S) and its supporting tools.
Luís Moreira de Sousa +1 more
doaj +1 more source
Language Architecture: An Architecture Language for Model-Driven Engineering
Proceedings of the 5th International Conference on Model-Driven Engineering and Software Development, 2017 The increasing number of languages used to engineer complex systems causes challenges to the development and maintenance processes of these languages. In this paper, we reflect on our experience in developing real life complex cyber-physical systems by using MDE techniques and DSLs.
Niels Brouwers +3 more
openaire +2 more sources
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
Incorporating Security Behaviour into Business Models Using a Model Driven Approach [PDF]
, 2007 There has, in recent years, been growing interest in Model Driven Engineering (MDE), in which models are the primary design artifacts and transformations are applied to these models to generate refinements leading to usable implementations over specific ...
Linington, Peter F. +3 more
core +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
A Model Driven Approach to Model Transformations
, 2003 The OMG's Model Driven Architecture (MDA) initiative has been the focus of much attention in both academia and industry, due to its promise of more rapid and consistent software development through the increased use of models.
Laurence Tratt +9 more
core