Results 91 to 100 of about 20,578 (261)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Ontology transformation and reasoning for model-driven architecture [PDF]
, 2005 Model-driven Architecture (MDA) is a software architecture framework proposed by the Object Management Group OMG. MDA emphasises the importance of modelling in the architectural design of service-based software systems.
Claus Pahl, Pahl, Claus
core +1 more source
Framework based on MDA and ontology for the representation and validation of components model
Revista Cubana de Ciencias Informáticas, 2014 Model Driven Architecture is one of the most prominent proposals in the area of software development, accepted by both the research community and software development industry.
Nemury Silega-Martínez +3 more
doaj
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Ingeniare: Revista Chilena de Ingeniería, 2012 Un data warehouse (DW) es un repositorio de datos que provienen de distintas fuentes. Es un sistema para el análisis de datos usado para el apoyo a la toma de decisiones.
Carolina Zambrano Matamala +2 more
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Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis
Molecular Oncology, EarlyView.LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini +1 more
wiley +1 more source
Graph-based implicit knowledge discovery from architecture change logs [PDF]
, 2012 Service architectures continuously evolve as a consequence of frequent business and technical change cycles. Architecture change log data represents a source of evolution-centric information in terms of intent, scope and operationalisation to ...
Pooyan Jamshidi (5276344) +12 more
core +1 more source
Ingeniare: Revista Chilena de Ingeniería, 2010 En el ámbito de las bases de datos, diversos métodos han sido propuestos para la generación del diseño lógico de un almacén de datos o data warehouse (DW), por otra parte, existen estudios que permiten el almacenamiento y operación de datos imprecisos o ...
Sabina Carrera Sepúlveda +2 more
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