Results 71 to 80 of about 20,578 (261)
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
Content-driven design and architecture of E-learning applications [PDF]
, 2008 E-learning applications combine content with learning technology systems to support the creation of content and its delivery to the learner. In the future, we can expect the distinction between learning content and its supporting infrastructure to become
Pahl, Claus
core +1 more source
α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates
FEBS Letters, EarlyView.Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino +2 more
wiley +1 more source
Maturity of Software Modelling and Model Driven Engineering: a Survey in the Italian Industry [PDF]
, 2012 Background: The main claimed advantage of Model-driven engineering is improvement in productivity. However, few information is available about its actual adoption during software development and maintenance in the industry.
Tiso, Alessandro +14 more
core +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Poole -- Model-Driven Architecture. ECOOP 2001.
, 2001 This paper surveys the core OMG MDA standards (i.e., UML, MOF, XMI and CWM) and discusses the current attempts at mapping these standards to J2EE, as examples of PIM-to-PSM translations that are currently under development.
John D. Poole +1 more
core
Model-driven testing with UML 2.0
, 2022 179187The UML 2.0 Testing Profile provides support for UML 2.0 based model-driven testing. This paper introduces a methodology of how to use the profile in order to transform an existing UML system design model for tests.
Dai, Zhen Ru
core
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Extending the Model Driven Architecture with a preCIM level
, 2008 Whilst the successful alignment of business strategy and IT development is an important topic, there are still few ways that this is possible. The Model Driven Architecture (MDA) shows promise as an approach but is focussed firmly in the IT domain at ...
Phalp, Keith T. +2 more
core
Reliability prediction in model driven development
, 2005 Evaluating the implications of an architecture design early in the software development lifecycle is important in order to reduce costs of development.
David S. Rosenblum +6 more
core +1 more source