Results 51 to 60 of about 313,524 (264)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Quality-Driven Detection and Resolution of Metamodel Smells
IEEE Access, 2019 In model-driven engineering, analogously to any software development practice, metamodel design must be accurate and performed by considering relevant quality factors, including maintainability, reusability, and understandability.
Lorenzo Bettini +3 more
doaj +1 more source
A Sketch of a Model-Driven Approach to Develop Smart Tourism Mobile Applications
Computer Sciences & Mathematics Forum, 2023 Several approaches have been proposed to accelerate software development. Model-driven engineering (MDE) is one approach that aims to abstract and automate the development process using models and transformations as the main artifacts.
Hamza Abdelmalek +3 more
doaj +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Towards an effective approach for composition of model transformations
Frontiers in Computer ScienceModel Driven Engineering (MDE) adoption in the industry suffers from many technical and non-technical problems. One of the significant technical problems lies in the difficulty of building complex transformations from the composition of small and ...
Hamza Abdelmalek +2 more
doaj +1 more source
Engineering Science and Technology, an International Journal, 2021 Good domain-modeling enables an appropriate separation of concerns that improves quality properties in the simulation models, such as modifiability and maintainability.
María Julia Blas, Silvio Gonnet
doaj +1 more source
Program translation using model-driven engineering
Proceedings of the ACM/IEEE 44th International Conference on Software Engineering: Companion Proceedings, 2022 This is the dataset of examples and executables for our ICSE paper.
openaire +2 more sources
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Quality-Aware Model-Driven Service Engineering [PDF]
, 2009 Service engineering and service-oriented architecture as an integration and platform technology is a recent approach to software systems integration. Quality aspects ranging from interoperability to maintainability to performance are of central importance for the integration of heterogeneous, distributed service-based systems.
Pahl, Claus +3 more
openaire +2 more sources