Results 71 to 80 of about 19,227,835 (243)

A formal foundation for transformations in model driven engineering

Journal of Computer Science and Technology, 2008
In the MDE (Model Driven Engineering) paradigm, models are thought to be the primary conductors in all software development aspects. A PIM (Platform Independent Model) is transformed into one or more PSMs (Platform Specific Model); hence, a specific PSM ...
Roxana Silvia Giandini
doaj  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Foundations of Model (Driven) (Reverse) Engineering: Models -- Episode I: Stories of the Fidus Papyrus and of the Solarus [PDF]

, 2004
Model Driven Engineering (MDE) received a lot of attention in the last years, both from academia and industry. However, there is still a debate on which basic concepts form the foundation of MDE.
Jean-Marie Favre, Favre, Jean-Marie
core   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Meadmore Model Engineering Company.

, 1920
Cover subtitle: Scale models of all varieties.; Electronic reproduction. Canberra, A.C.T.
Meadmore Model Engineering Co.
core  

CSIMQ Anniversary Editor-in-Chief Thoughts and Editorial Introduction to Issue 38: Model-based and Decision Support Methods for Next-generation Information Systems

Complex Systems Informatics and Modeling Quarterly
The 38th issue of CSIMQ comprises four articles selected by guest issue editors on topics related to novel decision support methods or model-based frameworks for evolving or evaluating information systems.
Anders Flodström, Robert Andrei Buchmann, Andrea Morichetta   +2 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Model-Driven Engineering Practices in Industry

, 2011
In this paper, we attempt to address the relative absence of empirical studies of model driven engineering through describing the practices of three commercial organizations as they adopted a model driven engineering approach to their software ...
Rouncefield, Mark, Hutchinson, John, Whittle, Jon   +2 more
core   +3 more sources

Model-Driven Engineering Techniques and Tools for Machine Learning-Enabled IoT Applications: A Scoping Review. [PDF]

Sensors (Basel), 2023
Mardani Korani Z, Moin A, Rodrigues da Silva A, Ferreira JC.   +3 more
europepmc   +1 more source