Results 71 to 80 of about 388,807 (307)
Scalability in Model Driven Engineering
, 2013 As Model Driven Engineering (MDE) is increasingly applied to larger and more complex systems, the current generation of modelling and model management technologies are being pushed to their limits in terms of capacity and efficiency.
Di Ruscio, Davide +5 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Dirty engineering data-driven inverse prediction machine learning model
Scientific Reports, 2020 Most data-driven machine learning (ML) approaches established in metallurgy research fields are focused on a build-up of reliable quantitative models that predict a material property from a given set of material conditions.
Jin-Woong Lee +5 more
doaj +1 more source
Towards Model-Driven Development of Access Control Policies for Web Applications [PDF]
, 2012 We introduce a UML-based notation for graphically modeling systems’ security aspects in a simple and intuitive way and a model-driven process that transforms graphical specifications of access control policies in XACML.
N. Koch +13 more
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Model-Driven Approaches for Reverse Engineering—A Systematic Literature Review
IEEE AccessMany organizations depend on software systems to accomplish their daily tasks, but these systems need to be maintained and evolved to cope with various changes and requirements.
Hanan Abdulwahab Siala +2 more
doaj +1 more source
An Integrated Modeling, Simulation and Analysis Framework for Engineering Complex Systems
IEEE Access, 2019 The discipline of component-based modeling and simulation offers promising gains in reducing cost, time, and the complexity of model development through the (re)use of modular components.
Imran Mahmood +4 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Semantic model driven engineering
, 2020 Semantic interoperability is a concern in the design and implementation of modern information systems. Whenever two systems communicate it is important that they share an adequate, common interpretation of any information transferred. Similarly, whenever data created or ac- quired in one context is used in another, it is important that the provenance ...
openaire +3 more sources
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source