Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Challenging Models: Formalizing Quests in Gamified Systems for Behavioral Change
, 2023 Tasks performed by users in exchange for some reward, also known as quests or challenges, are one of the essential elements found in gamified systems, including systems for behavioral change.
Bonetti, Federico +3 more
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Scalability in Model Driven Engineering
, 2013 As Model Driven Engineering (MDE) is increasingly applied to larger and more complex systems, the current generation of modelling and model management technologies are being pushed to their limits in terms of capacity and efficiency.
Di Ruscio, Davide +5 more
core +1 more source
A Scholarship Approach to Model-Driven Engineering [PDF]
, 2014 Model-Driven Engineering is a paradigm for software engineering where software models are the primary artefacts throughout the software life-cycle.
Burden, Håkan
core +1 more source
Model-driven engineering of safety and security software systems: A systematic mapping study and future research directions. [PDF]
J Softw (Malden), 2023 Mashkoor A, Egyed A, Wille R, Stock S.
europepmc +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
MDWEnet: a practical approach to achieving interoperability of model-driven web engineering methods [PDF]
, 2007 Current model-driven Web Engineering approaches (such as OO-H, UWE or WebML) provide a set of methods and supporting tools for a systematic design and development of Web applications.
Rivera, José E. +36 more
core
Model-driven engineering city spaces via bidirectional model transformations. [PDF]
Softw Syst Model, 2021 Visconti E, Tsigkanos C, Hu Z, Ghezzi C.
europepmc +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source