Results 81 to 90 of about 388,807 (307)

Model Driven Language Engineering

open access: yesElectronic Notes in Theoretical Computer Science, 2003
AbstractThere is currently much interest in model driven approaches to software engineering. The basic idea is to make business, architecture and design models frst class artefacts that are not discarded once the code gets built, but rather can be exercised independently, be reconciled with each other and underlying implementations, and used to ...
openaire   +1 more source

Software evolution in model-driven product line engineering [PDF]

open access: yes, 2012
New requirements and technology changes lead to continuous changes of the assets comprising a software product line. Since the product line represents a large number of potential products (or already deployed products) in a given domain, managing these
Abrahao Gonzales, Silvia Mara   +3 more
core  

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

VIDEAS : Supporting Answer-Set ProgramDevelopment using Model-Driven Engineering Techniques

open access: yes, 2011
Recently, the techniques of model-driven engineering (MDE) have been proven valuable to manage the complexity of modern software systems during the software development process.
Zwickl, Patrick,   +4 more
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Agile Development of PHP Websites: A Model-Aware Approach

open access: yesComplex Systems Informatics and Modeling Quarterly, 2020
The Design Science research method was hereby employed to develop an artifact that demonstrates the experimental “model-aware” software engineering methodology in the context of PHP Web development – a “low code” development approach with code templates ...
Carmen Ioana Gog
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Model-driven engineering applied to crop modeling

open access: yesEcological Informatics, 2015
Abstract At the crossroads of two disciplines, Computer Science and Agronomy, we propose the use of Model-Driven Engineering which has the potential to be the future of software engineering. This work was initiated to tackle issues met by the ITK Company in developing and designing new crop models for decision support systems.
Barbier, Guillaume   +2 more
openaire   +1 more source

A brief introduction to model-driven engineering

open access: yesTecnura, 2014
La crisis del software es un concepto que comenzó a utilizarse en 1968, en la primera conferencia organizada por la Organización del Tratado del Atlántico Norte (OTAN) en el desarrollo de software.
Vicente García Díaz   +5 more
doaj  

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