Results 101 to 110 of about 1,785,688 (300)
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Model-Driven Engineering Techniques and Tools for Machine Learning-Enabled IoT Applications: A Scoping Review. [PDF]
Sensors (Basel), 2023 Mardani Korani Z +3 more
europepmc +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Complex Systems Informatics and Modeling QuarterlyThe 38th issue of CSIMQ comprises four articles selected by guest issue editors on topics related to novel decision support methods or model-based frameworks for evolving or evaluating information systems.
Anders Flodström +2 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Model-driven engineering of safety and security software systems: A systematic mapping study and future research directions. [PDF]
J Softw (Malden), 2023 Mashkoor A, Egyed A, Wille R, Stock S.
europepmc +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Model-driven engineering city spaces via bidirectional model transformations. [PDF]
Softw Syst Model, 2021 Visconti E, Tsigkanos C, Hu Z, Ghezzi C.
europepmc +1 more source
How do we teach modelling and model-driven engineering?: a survey
ACM/IEEE International Conference on Model Driven Engineering Languages and Systems, 2018 Understanding the experiences of instructors teaching modelling and model-driven engineering is of great relevance to determining how MDE courses should be managed in terms of content, assessment, and teaching methods.
Federico Ciccozzi +11 more
semanticscholar +1 more source