Results 111 to 120 of about 1,785,688 (300)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Distributed embedded control systems design with verification support
Моделирование и анализ информационных систем, 2010 We consider a problem of integrating a formal method of verification (model checking) into the process of designing complex distributed software systems to improve the quality of software. We use an approach based on the Model-Driven Engineering.
I. V. Shoshmina
doaj
Systematic Reviews in Model-Driven Engineering: A Tertiary study
Havacılık ve Uzay Teknolojileri Dergisi, 2020 To cope with growing complexity of software-intensive systems, model-driven engineering (MDE) has become a widely used approach in the industry by providing many (potential) benefits with different purposes. Although there has been an increasing interest
Deniz Akdur, Onur Demirörs
doaj
Practitioners’ experiences with model-driven engineering: a meta-review
Journal of Software and Systems Modeling, 2022 Charlotte Verbruggen, M. Snoeck
semanticscholar +1 more source
MCQGen: A Large Language Model-Driven MCQ Generator for Personalized Learning
IEEE AccessIn the dynamic landscape of contemporary education, the evolution of teaching strategies such as blended learning and flipped classrooms has highlighted the need for efficient and effective generation of multiple-choice questions (MCQs). To address this,
Ching Nam Hang, Chee Wei Tan, Pei-Duo Yu
semanticscholar +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source