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Complex Systems Informatics and Modeling QuarterlyThe 38th issue of CSIMQ comprises four articles selected by guest issue editors on topics related to novel decision support methods or model-based frameworks for evolving or evaluating information systems.
Anders Flodström +2 more
doaj +1 more source
, 2014 Designing complex engineering systems, such as an aircraft or an aero-engine, is immensely challenging. Formal Systems Engineering (SE) practices are widely used in the aerospace industry throughout the overall design process to minimise the overall ...
Bertoni, M. +3 more
core +3 more sources
Model-driven engineering of safety and security software systems: A systematic mapping study and future research directions. [PDF]
J Softw (Malden), 2023 Mashkoor A, Egyed A, Wille R, Stock S.
europepmc +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Model-driven engineering city spaces via bidirectional model transformations. [PDF]
Softw Syst Model, 2021 Visconti E, Tsigkanos C, Hu Z, Ghezzi C.
europepmc +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Combining Model-Driven Engineering and Cloud Computing [PDF]
, 2010 Service-orientation and model-driven engineering are two of the most dominant software engineering paradigms nowadays. This position paper explores the synergies between them and show how they can benefit from each other.
Bruneliere, Hugo +2 more
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
MDWEnet: a practical approach to achieving interoperability of model-driven web engineering methods [PDF]
, 2007 Current model-driven Web Engineering approaches (such as OO-H, UWE or WebML) provide a set of methods and supporting tools for a systematic design and development of Web applications.
Cachero, Cristina +19 more
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