Results 111 to 120 of about 388,807 (307)

Model-driven engineering city spaces via bidirectional model transformations. [PDF]

Softw Syst Model, 2021
Visconti E, Tsigkanos C, Hu Z, Ghezzi C.
europepmc   +1 more source

Towards Agent-oriented Model-Driven Architecture

, 2007
Model Driven Architecture supports the transformation from reusable models to executable software. Business representations, however, cannot be fully and explicitly represented in such models for direct transformation into running systems.
Xiao, Liang, Greer, Des
core  

Semantic model-driven development of service-centric software architectures [PDF]

, 2007
Service-oriented architecture (SOA) is a recent architectural paradigm that has received much attention. The prevalent focus on platforms such as Web services, however, needs to be complemented by appropriate software engineering methods.
Pahl, Claus, Barrett, Ronan
core  

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Reliability prediction in model driven development

, 2005
Evaluating the implications of an architecture design early in the software development lifecycle is important in order to reduce costs of development.
David S. Rosenblum, Genaı́na N. Rodrigues, Genaína N. Rodrigues, Rosenblum, D.S., Uchitel, S., Rodrigues, G.N., Sebastian Uchitel   +6 more
core   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

MDWEnet: a practical approach to achieving interoperability of model-driven web engineering methods

, 2007
Current model-driven Web Engineering approaches (such as OO-H, UWE or WebML) provide a set of methods and supporting tools for a systematic design and development of Web applications.
Rivera, José E., W. Retschitzegger, Matera, Maristella, Fraternali, Piero, Cachero, Cristina, J. E. Rivera, Pröll, Birgit, I. Garrigós, Knapp, Alexander, Comai, Sara, Vallecillo, Antonio, A. Knapp, T. Reiter, Kappel, Gerti, Schauerhuber, Andrea, C. Cachero, Retschitzegger, Werner, G. Zhang, N. Koch, B. Pröll, Koch, Nora, G. Kappel, A. Schauerhuber, Wimmer, Manuel, Gómez Ortega, Jaime, Meliá, Santiago, J. Gómez, Moreno, Nathalie, S. Meliá, Reiter, Thomas, Garrigós, Irene, Schwinger, Wieland, Zhang, Gefei, W. Schwinger, N. Moreno, A. Vallecillo, M. Wimmer   +36 more
core  

Preliminary findings from a survey on the MD state of the practice [PDF]

, 2011
In the context of an Italian research project, this paper reports on an on-line survey, performed with 155 software professionals, with the aim of investigating about their opinions and experiences in modeling during software development and Model-driven
Ricca F., Tiso A., Tomassetti, Federico Cesare Argentino, Reggio, G., REGGIO, GIANNA, Ricca, F., Tiso, A., Gianna Reggio, Reggio G., F. Tomassetti, Federico Tomassetti, RICCA, FILIPPO, Alessandro Tiso, Filippo Ricca, M. Torchiano, A. Tiso, Torchiano, Marco, Marco Torchiano   +17 more
core   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source