Results 91 to 100 of about 1,764,274 (298)

Principles for aerospace manufacturing engineering in integrated new product introduction [PDF]

, 2013
This article investigates the value-adding practices of Manufacturing Engineering for integrated New Product Introduction. A model representing how current practices align to support lean integration in Manufacturing Engineering has been defined.
Beadle, Chris, Carswell, Matt, Maginness, Malachy, Shehab, Essam   +3 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Agile Development of PHP Websites: A Model-Aware Approach

Complex Systems Informatics and Modeling Quarterly, 2020
The Design Science research method was hereby employed to develop an artifact that demonstrates the experimental “model-aware” software engineering methodology in the context of PHP Web development – a “low code” development approach with code templates ...
Carmen Ioana Gog
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Model-driven engineering applied to crop modeling

Ecological Informatics, 2015
Abstract At the crossroads of two disciplines, Computer Science and Agronomy, we propose the use of Model-Driven Engineering which has the potential to be the future of software engineering. This work was initiated to tackle issues met by the ITK Company in developing and designing new crop models for decision support systems.
Barbier, Guillaume, Cucchi, Véronique, Hill, David R.C.   +2 more
openaire   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Quality Issues on Model-Driven Web Engineering Methodologies [PDF]

, 2009
Nowadays, there are several development methodologies in the field of model-driven web engineering (MDWE) which involve different levels of modeldriven architecture (MDA): CIM, PIM, PSM, or code. Attending to the high number of available methodologies,
Domínguez Mayo, Francisco José, Escalona Cuaresma, María José, Mejías Risoto, Manuel   +2 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Model Driven Engineering with Capella and AADL [PDF]

, 2016
The development of real time embedded equipments is a challenging task that requires the elaboration of multiple models in several domains, notably system, electronics and software, spanning a large spectrum of multiple abstraction levels and viewpoints:
Gaufillet, Pierre, Hugues, Jérôme, Jenn, Eric, Ouni, Bassem   +3 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source