Results 91 to 100 of about 388,807 (307)
A Scholarship Approach to Model-Driven Engineering
, 2014 Model-Driven Engineering is a paradigm for software engineering where software models are the primary artefacts throughout the software life-cycle.
Burden, Håkan
core +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
A formal foundation for transformations in model driven engineering
Journal of Computer Science and Technology, 2008 In the MDE (Model Driven Engineering) paradigm, models are thought to be the primary conductors in all software development aspects. A PIM (Platform Independent Model) is transformed into one or more PSMs (Platform Specific Model); hence, a specific PSM ...
Roxana Silvia Giandini
doaj
A requirements engineering methodology combining models and controlled natural
, 2022 S.67-76The use of models in requirements engineering (RE) for software-intensive embedded systems is considered beneficial. The main advantages of requirements models as documentation format are that they facilitate requirements understanding and foster ...
Fockel, Markus, Holtmann, Jörg
core +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Maturity of model driven engineering for embedded control systems from a mechatronic perspective
, 2005 Model driven engineering (MDE), as one key technique for promotingquality and cost-efficiency in the development of embedded systems, is currentlystudied intensively both in industry and academia.
Larses, Ola,, Törngren, Martin,
core
Industrial requirements for supporting AI-enhanced model-driven engineering
, 2022 There is an increasing interest in research on the combination of AI techniques and methods with MDE. However, there is a gap between AI and MDE practices, as well as between researchers and practitioners.
Strandberg, P. E., +1 more
core +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source