Results 61 to 70 of about 313,524 (264)
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Model-Driven Approaches for Reverse Engineering—A Systematic Literature Review
IEEE AccessMany organizations depend on software systems to accomplish their daily tasks, but these systems need to be maintained and evolved to cope with various changes and requirements.
Hanan Abdulwahab Siala +2 more
doaj +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
An Integrated Modeling, Simulation and Analysis Framework for Engineering Complex Systems
IEEE Access, 2019 The discipline of component-based modeling and simulation offers promising gains in reducing cost, time, and the complexity of model development through the (re)use of modular components.
Imran Mahmood +4 more
doaj +1 more source
Dirty engineering data-driven inverse prediction machine learning model
Scientific Reports, 2020 Most data-driven machine learning (ML) approaches established in metallurgy research fields are focused on a build-up of reliable quantitative models that predict a material property from a given set of material conditions.
Jin-Woong Lee +5 more
doaj +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
A brief introduction to model-driven engineering
Tecnura, 2014 La crisis del software es un concepto que comenzó a utilizarse en 1968, en la primera conferencia organizada por la Organización del Tratado del Atlántico Norte (OTAN) en el desarrollo de software.
Vicente García Díaz +5 more
doaj
Agile Development of PHP Websites: A Model-Aware Approach
Complex Systems Informatics and Modeling Quarterly, 2020 The Design Science research method was hereby employed to develop an artifact that demonstrates the experimental “model-aware” software engineering methodology in the context of PHP Web development – a “low code” development approach with code templates ...
Carmen Ioana Gog
doaj +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source