Results 61 to 70 of about 1,030,481 (267)

Prediction model for transmission line icing based on data assimilation and model integration

open access: yesFrontiers in Environmental Science
With the increase of extreme weather events such as cold waves, power transmission line icing has become more and more severe, affecting the safe and stable operation of power systems. Thus, icing prediction has become crucial for power grids.
Guoyu Wang   +5 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Large-scale executable biology using rapid integration of computational models [PDF]

open access: yesComputer Science Journal of Moldova, 2016
We plan to develop a systematic framework for assembling large-scale computational biological models by reusing and combining already existing modelling efforts.
Vladimir Rogojin, Ion Petre
doaj  

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

A Literature Review of the Digital Thread: Definition, Key Technologies, and Applications

open access: yesSystems
The digital thread, as a crucial technology for industrial digitization and the realization of smart manufacturing, has garnered extensive attention and research in recent years. Furthermore, there is a growing interest in the key technologies supporting
Qiang Zhang, Jihong Liu, Xu Chen
doaj   +1 more source

To bucket or not to bucket? Analyzing the performance and interpretability of hybrid hydrological models with dynamic parameterization [PDF]

open access: yesHydrology and Earth System Sciences
Hydrological hybrid models have been proposed as an option to combine the enhanced performance of deep learning methods with the interpretability of process-based models.
E. Acuña Espinoza   +4 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

An integrable SIS model

open access: yesJournal of Mathematical Analysis and Applications, 2004
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
NUCCI, Maria Clara, P. G. L. LEACH
openaire   +2 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

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