Results 71 to 80 of about 1,030,481 (267)

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Integration Flow Models

CoRR
Ordinary differential equation (ODE) based generative models have emerged as a powerful approach for producing high-quality samples in many applications. However, the ODE-based methods either suffer the discretization error of numerical solvers of ODE, which restricts the quality of samples when only a few NFEs are used, or struggle with training ...
Jingjing Wang, Dan Zhang, Joshua Luo, Yin Yang, Feng Luo   +4 more
openaire   +2 more sources

Analyzing the generalization capabilities of a hybrid hydrological model for extrapolation to extreme events [PDF]

Hydrology and Earth System Sciences
Data-driven techniques have shown the potential to outperform process-based models in rainfall–runoff simulation. Recently, hybrid models, which combine data-driven methods with process-based approaches, have been proposed to leverage the strengths of ...
E. Acuña Espinoza, R. Loritz, F. Kratzert, D. Klotz, D. Klotz, M. Gauch, M. Álvarez Chaves, U. Ehret   +7 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Weakly supervised semantic segmentation and optimization algorithm based on multi-scale feature model

Tongxin xuebao, 2019
In order to improve the accuracy of weakly-supervised semantic segmentation method,a segmentation and optimization algorithm that combines multi-scale feature was proposed.The new algorithm firstly constructs a multi-scale feature model based on transfer
Changzhen XIONG, Hui ZHI
doaj  

Empirical model integration for accurate charge carrier mobility simulation in silicon MOSFETs

Open Physics
This study investigates the use of combined empirical models to improve charge carrier mobility simulation in silicon MOSFETs, overcoming the limitations of conventional single-model approaches.
Bourbaba Elhouaria, Kadri Syham, Bensafi Mohammed, Larguech Samia, Menni Younes, Alshammari Badr M., Kolsi Lioua   +6 more
doaj   +1 more source

Technical note: An approach for handling multiple temporal frequencies with different input dimensions using a single LSTM cell [PDF]

Hydrology and Earth System Sciences
Long short-term memory (LSTM) networks have demonstrated state-of-the-art performance for rainfall-runoff hydrological modelling. However, most studies focus on predictions at a daily scale, limiting the benefits of sub-daily (e.g. hourly) predictions in
E. Acuña Espinoza, F. Kratzert, D. Klotz, D. Klotz, M. Gauch, M. Álvarez Chaves, R. Loritz, U. Ehret   +7 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Integrating models and integrated models: towards a unified model of information seeking behaviour

Information Research: an international electronic journal, 2022
Introduction. There has been a proliferation of information seeking models and theories, each incorporating different viewpoints, concepts, and terminology. While there have been prior attempts at integration, they have all focused on different facets of information seeking behaviour. Method / Analysis.
openaire   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source