Results 141 to 150 of about 15,975 (254)

Incorporating scale uncertainty in microbiome and gene expression analysis as an extension of normalization

Genome Biology
Statistical normalizations are used in differential analyses to address sample-to-sample variation in sequencing depth. Yet normalizations make strong, implicit assumptions about the scale of biological systems, such as microbial load, leading to false ...
Michelle Pistner Nixon, Gregory B. Gloor, Justin D. Silverman   +2 more
doaj   +1 more source

Mirikizumab pharmacokinetics and exposure–response in pediatric patients with moderate‐to‐severe ulcerative colitis

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 474-485, March 2025.
Abstract Mirikizumab is a p19‐directed anti‐interleukin‐23 antibody approved for the treatment of adults with moderate‐to‐severe ulcerative colitis (UC). Here, we report the first data of mirikizumab pharmacokinetics (PK) and exposure–response (E/R) relationships in pediatric participants (aged 2 to <18 years weighing >10 kg) with moderate‐to‐severe UC
Yuki Otani, Laiyi Chua, Wendy J. Komocsar, Amy Larkin, Jordan Johns, Xin Zhang   +5 more
wiley   +1 more source

Advancing pharmacometrics in Africa—Transition from capacity development toward job creation

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 407-419, March 2025.
Abstract Trained pharmacometricians remain scarce in Africa due to limited training opportunities, lack of a pharmaceutical product development ecosystem, and emigration to high‐income countries. The Applied Pharmacometrics Training (APT) fellowship program was established to address these gaps and specifically foster job creation for talent retention.
Goonaseelan (Colin) Pillai, Samer Mouksassi, Innocent G. Asiimwe, Craig R. Rayner, Steven Kern, Phumla Sinxadi, Paolo Denti, Eric Decloedt, Catriona Waitt, Bernhards R. Ogutu, Rik de Greef   +10 more
wiley   +1 more source

Mechanistic Learning for Predicting Survival Outcomes in Head and Neck Squamous Cell Carcinoma

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 540-550, March 2025.
ABSTRACT We employed a mechanistic learning approach, integrating on‐treatment tumor kinetics (TK) modeling with various machine learning (ML) models to address the challenge of predicting post‐progression survival (PPS)—the duration from the time of documented disease progression to death—and overall survival (OS) in Head and Neck Squamous Cell ...
Kevin Atsou, Anne Auperin, Jôel Guigay, Sébastien Salas, Sebastien Benzekry   +4 more
wiley   +1 more source

Hybrid physics–data‐driven modeling for sea ice thermodynamics and transfer learning

Quarterly Journal of the Royal Meteorological Society, EarlyView.
Icepack–NN, a machine‐learning‐based hybrid version of the sea‐ice column model Icepack, is developed to correct state‐dependent forecast errors arising from misspecified snow thermodynamics, using neural networks applied online within the physical model.
G. De Cillis, A. Carrassi, J. Brajard, L. Bertino, M. Broccoli, D. Iovino, T.S. Finn, M. Bocquet   +7 more
wiley   +1 more source

Spatial observation‐error correlations for AMSU‐A in all‐sky assimilation: An ECMWF and UK Met Office intercomparison

Quarterly Journal of the Royal Meteorological Society, EarlyView.
Assimilation of AMSU‐A all‐sky observations can be increased up to fivefold if spatial observation‐error correlations are accounted for properly. New correlation estimates derived using data from ECMWF and the UK Met Office reveal that correlation length‐scales are between 75 and 150 km for AMSU‐A channels peaking in the troposphere. This is attributed
Rishabh Bhatt, Massimo Bonavita, Niels Bormann, Sarah L. Dance, Alison Fowler, Elías Hólm, Christopher J. Merchant, Jonathan Mittaz, Stuart Newman, Joanne Waller   +9 more
wiley   +1 more source

A new phylogenetic protocol: dealing with model misspecification and confirmation bias in molecular phylogenetics. [PDF]

NAR Genom Bioinform, 2020
Jermiin LS, Catullo RA, Holland BR.
europepmc   +1 more source

Unlocking Financial Inclusion: The Dynamics of Bank Account Ownership in Urban Slums

Sustainable Development, EarlyView.
ABSTRACT Financial inclusion is a key driver of sustainable development, contributing to poverty reduction (SDG 1), gender equality (SDG 5), and reduced inequalities (SDG 10). Despite extensive financial‐inclusion policies in India, residents of urban slums remain largely excluded from formal banking systems.
Davide Moro, Sivia Trentin, Lucia Dalla Pellegrina, Paolo Landoni   +3 more
wiley   +1 more source

From Green Strategy to Sustainable Development: Corporate Efforts Toward SDG 12 and SDG 13

Sustainable Development, EarlyView.
ABSTRACT Firms are increasingly integrating United Nations Development Goals 12 (Responsible consumption and production) and 13 (Climate action) as a part of their sustainability strategies. However, prior research has rarely examined how these SDGs interact as a unified capability rather than as isolated practices.
Post Raj Pokharel
wiley   +1 more source

Decision-Making Under Model Misspecification: DRO with Robust Bayesian Ambiguity Sets. [PDF]

Entropy (Basel)
Dellaporta C, O'Hara P, Damoulas T.
europepmc   +1 more source